Cyclopalladated, phosphine free, 8-methyl quinoline based complexes (2a–j) are excellent catalysts for the Heck vinylation of aryl iodides and bromides with turnover numbers of greater than 25 million observed in some cases. The catalysts are air and moisture stable.
842. The cyclodehydration of anils. Part IV. Substituent effects
作者:T. G. Bonner、Mary Barnard
DOI:10.1039/jr9580004181
日期:——
Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide<i>N</i>-Methyltransferase
作者:Harshini Neelakantan、Hua-Yu Wang、Virginia Vance、Jonathan D. Hommel、Stanton F. McHardy、Stanley J. Watowich
DOI:10.1021/acs.jmedchem.7b00389
日期:2017.6.22
biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure–activityrelationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogues resulted in the