2,5-二羟基苯磺酸 | 88-46-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,5-二羟基苯磺酸
• 中文别名: 环己羧酸,3,5-二[(4-叠氮苯基)亚甲基]-4-羰基；羟苯磺酸；3,5-二甲基苯乙酸
• 英文名称: dobesilate
• 英文别名: 2,5-dihydroxybenzenesulfonic acid；2,5-Dihydroxy-benzolsulfonsaeure；ethamsylate；etamsylate；dobesilic acid；Hydrochinon-2-sulfonsaeure
• CAS: 88-46-0
• 化学式: C₆H₆O₅S
• mdl: MFCD00065337
• 分子量: 190.177
• InChiKey: IKQCSJBQLWJEPU-UHFFFAOYSA-N

物化性质

• 密度：
  1.743±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,5-二羟基苯磺酸 在 硫酸 、 calcium carbonate 作用下， 以 水 为溶剂， 反应 0.25h， 生成 calcium dobesilate
  参考文献：
  名称：

  Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates

  摘要：

  Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was performed. The dobesilates were characterized by standard spectral methods and by AAS for metal content and then tested for inhibitory activity against aminopeptidase N. The calcium and magnesium 2,5-dihydroxybenzenesulfonates exhibited rather weak inhibitory activity to aminopeptidase N, as demonstrated by the IC50 values of 978.0 and 832.1 mu mol L-1, respectively, while zinc 2,5-dihydroxybenzenesulfonate reached a more significant inhibitory activity characterized by an IC50 value of 77.4 mu mol L-1. The results of the inhibition activity suggest that the inhibition of aminopeptidase N could play a role in the anti-angiogenic activity of 2,5-dihydroxybenzenesulfonates.

  DOI：

  10.2298/jsc131128032f
• 作为产物：
  描述：

  2,5-二氯苯磺酸 在 sodium hydroxide 作用下， 生成 2,5-二羟基苯磺酸
  参考文献：
  名称：

  DE284533

  摘要：

  公开号：

文献信息

• Synthetic Clay Excels in ⁹⁰Sr Removal
  作者：Sridhar Komarneni、Tatsuya Kodama、William J. Paulus、C. Carlson

  DOI：10.1557/jmr.2000.0182

  日期：2000.6

  ground water from Hanford site, and fundamental studies of 2Nasup +}yields}Srsup 2+} exchange equilibria revealed that a synthetic clay is extremely selective for sup 90}Sr with a high capacity for uptake. Comparative studies with existing Sr selective ion exchangers clearly revealed that the present synthetic clay exhibited the best performance for sup 90}Sr removal from actual ground water collected

  对来自汉福德场地的实际地下水进行的测试以及对 2Na sup +}产量}Srsup 2+} 交换平衡的基础研究表明，合成粘土对 sup 90}Sr 具有极高的选择性，具有很高的吸收能力。与现有 Sr 选择性离子交换剂的比较研究清楚地表明，本合成粘土表现出从汉福德三个不同位置收集的实际地下水中去除 sup 90}Sr 的最佳性能。这种新型 Sr 离子筛有望用于在意外释放和 sup 90}Sr 污染后净化环境。(c) 2000 材料研究学会。
• [EN] NOVEL BENZAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZAMIDE UTILES EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009068509A1

  公开（公告）日：2009-06-04

  This invention relates to novel benzamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  这项发明涉及新型苯甲酰胺衍生物，发现它们是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值候选药物。
• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• [EN] HIGH-AND LOW-POTENTIAL, WATER-SOLUBLE, ROBUST QUINONES<br/>[FR] QUINONES ROBUSTES SOLUBLES DANS L'EAU À POTENTIEL FAIBLE ET ÉLEVÉ
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2018160618A1

  公开（公告）日：2018-09-07

  Substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, and anthrahydroquinones are disclosed herein. The substituted hydroquinones and catechols have the formula: while the substituted 1,4-quinones or 1,2-have the corresponding oxidized structure (1,4- benzoquinones and 1,2-benzoquinones). One or more of R1, R2, R3 and R4 include a sulfonate moiety, a sulfonimide moiety, or a phosphonate moiety, and any of R1, R2, R3 and R4 that do not include one of these moieties include an alkyl, a cycloalkyl, a thioether, a sulfoxide, a sulfone, a haloalkyl, a halogen, a nitrile, an imide, a pyrazole, or combinations thereof. The substituted anthraquinones have the formula: while the substituted anthrahydroquinones have the corresponding reduced structure. One or more of R1-R8 have a sulfonate or phosphate tethered to the ring by a thi other, amine, or ether including one or more alkyl groups. Any of R1-R8 that do not contain one of these moieties include an alkyl, a cycloalkyl, a thiother, a sulfoxide, a sulfone, a haloalkyl, a halogen, a hydroxyl, an alkoxyl, an ether, an amine, or hydrogen The substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, or anthrahydroquinones are soluble in water, stable in aqueous acid solutions, and have useful reduction potentials in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.

  本文披露了取代的对苯二酚、1,4-喹啉醌、邻苯二酚、1,2-喹啉醌、蒽醌和蒽氢醌。取代的对苯二酚和邻苯二酚的化学式为：而取代的1,4-喹啉醌或1,2-喹啉醌具有相应的氧化结构（1,4-苯醌和1,2-苯醌）。R1、R2、R3和R4中的一个或多个包括磺酸酯基、磺酰胺基或膦酸酯基，而不包括这些基团之一的R1、R2、R3和R4包括烷基、环烷基、硫醚、亚硫醚、砜、卤代烷基、卤素、腈、酰亚胺、吡唑或其组合。取代的蒽醌的化学式为：而取代的蒽氢醌具有相应的还原结构。R1-R8中的一个或多个通过硫醚、胺或醚与环相连，包括一个或多个烷基。不含这些基团之一的R1-R8包括烷基、环烷基、硫醚、亚硫醚、砜、卤代烷基、卤素、羟基、烷氧基、醚、胺或氢的任何基团。取代的对苯二酚、1,4-喹啉醌、邻苯二酚、1,2-喹啉醌、蒽醌或蒽氢醌在水中溶解，在水酸性溶液中稳定，并且在氧化形式中具有有用的还原电位。因此，它们可以用作新兴技术中的氧化还原中介体，例如在介导燃料电池或有机介质流动电池中。
• 羟苯磺酸酯化合物及其制备方法
  申请人：湖北欣泽霏药业有限公司

  公开号：CN110981763A

  公开（公告）日：2020-04-10

  本发明公开了一种羟苯磺酸酯化合物及其制备方法，该方法首先将2,5‑二羟基苯磺酸与原甲酸三丙酯在反应溶剂中进行反应，再经过分离纯化得到羟苯磺酸酯化合物，如式(I)所示结构：式中，R为CH2CH2CH3或CH(CH3)2。本发明所述方法合成路线短，操作简单，大大降低羟苯磺酸酯的合成难度，且成本低廉、绿色环保，产品收率高，具有很好的样品制备基础和应用价值。