2,6-二乙炔基-4-甲氧基吡啶 | 680988-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,6-二乙炔基-4-甲氧基吡啶
• 英文名称: 2,6-diethynyl-4-methoxypyridine
• 英文别名: 2,6-bis(ethynyl)-4-methoxypyridine
• CAS: 680988-07-2
• 化学式: C₁₀H₇NO
• 分子量: 157.172
• InChiKey: SLJTVBPOSHRHTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-二乙炔基-4-甲氧基吡啶 在 高氯酸 、 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 乙醇 、 水 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  Activation of the Aromatic Core of 3,3′-(Pyridine-2,6-diylbis(1H-1,2,3-triazole-4,1-diyl))bis(propan-1-ol)—Effects on Extraction Performance, Stability Constants, and Basicity

  摘要：

  The "CHON" compatible water-soluble ligand 3,3'-(pyridine-2,6-diylbis(1H-1,2,3-triazole-4,1-diyl))bis-(propan-1-ol) (PTD) has shown promise for selectively stripping actinide ions from an organic phase containing both actinide and lanthanide ions, by preferential complexation of the former. Aiming at improving its complexation properties, PTD-OMe was synthesized, bearing a methoxy group on the central pyridine ring, thus increasing its basicity and hence complexation strength. Unfortunately, solvent extraction experiments in the range of 0.1-1 mol/L nitric acid proved PTD-OMe to be less efficient than PTD. This behavior is explained by its greater pK(a) value (pK(a) = 2.54) compared to PTD (pK(a) = 2.1). This counteracts its improved complexation properties for Cm(III) (log beta(3)(PTD-OMe) = 10.8 +/- 0.4 versus log beta(3)(PTD) = 9.9 +/- 0.5).

  DOI：

  10.1021/acs.inorgchem.9b02325
• 作为产物：
  描述：

  2,6-二氯吡啶N-氧化物 在 copper(l) iodide tris(dibenzylideneacetone)dipalladium (0) 、 硫酸 、 四丁基氟化铵 、 硝酸 、 potassium carbonate 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 81.44h， 生成 2,6-二乙炔基-4-甲氧基吡啶
  参考文献：
  名称：

  Pyridine-Containing m-Phenylene Ethynylene Oligomers Having Tunable Basicities

  摘要：

  Incorporation of a pyridine monomer into the backbone of a m-phenylene ethynylene oligomer allows functionalization of the interior binding cavity of the folded oligomer. The basicity of the inwardly directed pyridine moiety was modulated by changing the substituents on the pyridine ring and through oligomer folding, granting access to a pK(a) range of 5-14 in acetonitrile.

  DOI：

  10.1021/ol0363016

文献信息

• [EN] ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS<br/>[FR] AMÉLIORATION DE LA POLYMÉRISATION D'ACIDES NUCLÉIQUES PAR DES COMPOSÉS AROMATIQUES
  申请人：STRATOS GENOMICS INC

  公开号：WO2019135975A1

  公开（公告）日：2019-07-11

  The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.

  本发明涉及化合物、方法和组合物，用于改善核酸聚合，包括通过体外引物延伸的DNA复制，以生成例如纳米孔单分子测序的聚合物的方法。提供一种含有聚合增强物的核酸聚合酶反应组合物，其允许使用核苷酸类似物增强DNA聚合酶活性，从而改善引物延伸产物的长度，以用于测序应用。
• A pyrene-pyridyl nanooligomer as a methoxy-triggered reactive probe for highly specific fluorescence assaying of hypochlorite
  作者：Li Zhang、Yi Xiao、Wensheng Mao、Jiyan Huang、Hongmei Huang、Ronghua Yang、Youyu Zhang、Xiaoxiao He、Kemin Wang

  DOI：10.1039/d1cc06606d

  日期：——

  A novel pyrene-pyridyl conjugated oligomer (OPP-OMe) was conveniently prepared by one-pot Sonogashira coupling. Intriguingly, it was found that introducing only one methoxy moiety at the 4-pyridyl position can be sufficient for creating an oligomer-based ultrafine reactive fluorescent nanoprobe, i.e., OPP-OMe NPs (ca. 2.5 nm in diameter). Spectral analyses and elucidation of the intermediate structure

  通过一锅 Sonogashira 偶联方便地制备了一种新型芘-吡啶基共轭低聚物 (OPP-OMe)。有趣的是，发现仅在 4-吡啶基位置引入一个甲氧基部分就足以产生基于低聚物的超细反应性荧光纳米探针，即OPP-OMe NPs（直径约2.5 nm）。光谱分析和中间结构的阐明表明，甲氧基触发氧化以及 OPP-OMe NPs 的纳米聚集导致次氯酸盐的快速、特异性和超灵敏传感（LOD，0.3 nM，S/N = 3）。
• Single-Site Modifications and Their Effect on the Folding Stability of <i>m</i>-Phenylene Ethynylene Oligomers
  作者：Hirofumi Goto、Jennifer M. Heemstra、David J. Hill、Jeffrey S. Moore

  DOI：10.1021/ol036376+

  日期：2004.3.1

  The folded structure of a m-phenylene ethynylene oligomer is tolerant to single-site modifications to both the backbone sequence and end groups. The helical structure is reinforced by multiple noncovalent interactions, allowing the oligomer sequence to be customized without a significant change in stability in most cases. The small changes that are observed are consistent with the expected behavior of pi-stacked systems and demonstrate subtle control over folding through single-site modifications.
• ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS
  申请人：Stratos Genomics Inc.

  公开号：EP3735409A1

  公开（公告）日：2020-11-11