海藻酸铵 | 9005-34-9

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 海藻酸铵
• 英文名称: 6-(2-Carboxy-4,5-dihydroxy-6-methoxyoxan-3-yl)oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid
• CAS: 9005-34-9
• 化学式: C₁₄H₂₂O₁₃
• 分子量: 398.32
• InChiKey: GKFPPCXIBHQRQT-UHFFFAOYSA-N

物化性质

• 溶解度：
  Dissolves slowly in water to form a viscous solution; insoluble in ethanol and in ether.
• 物理描述：
  White to yellowish fibrous or granular powder
• 颜色/状态：
  FILAMENTOUS, GRAINY, GRANULAR, OR POWDERED; COLORLESS OR SLIGHTLY YELLOW
• 气味：
  SLIGHT CHARACTERISTIC SMELL
• 味道：
  SLIGHT CHARACTERISTIC TASTE
• 稳定性/保质期：

  在常温常压下保持稳定，请避免光照、明火及高温环境。

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  202
• 氢给体数：
  6
• 氢受体数：
  13

ADMET

毒理性

• 非人类毒性摘录

申请在动物上进行的实验性伤口处理，在应用部位没有造成伤害，也没有延迟愈合。/藻酸/

APPLICATION TO EXPTL WOUNDS IN ANIMALS PRODUCED NO INJURY @ SITE OF APPLICATION, & NO RETARDATION OF HEALING. /ALGINIC ACID/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

从裙带菜（Laminaria digitata）中提取的琼脂糖（Alginate）未被以每日饮食的10%水平喂养的大鼠吸收。/琼脂糖/

ALGINATE PREPARED FROM LAMINARIA DIGITATA WAS UNABSORBED BY RATS FED AT LEVEL OF 10% OF THEIR DAILY DIET. /ALGINATE/

来源:Hazardous Substances Data Bank (HSDB)

制备方法与用途

根据提供的信息，海藻酸铵是一种白色至浅黄色纤维状粉末或粗粉，几乎无臭无味。以下是关于海藻酸铵的一些关键信息：

化学性质：

• 溶解性：缓慢溶于水形成粘稠胶体溶液。
• 不溶性：不溶于乙醇含量高于约30%(wt)的乙醇溶液和氢化醇的溶液、氯仿、乙醚及pH值低于3的酸溶液。

用途：

1. 稳定剂
2. 增稠剂
3. 乳化剂
4. 色素稀释剂
5. **凝胶形成剂

含量分析与毒性

• 含量测定：按GT-7脱羧法测定，每ml。0.25mol/L氢氧化钠液相当于5.5mg二氧化碳(CO₂)或27.12mg海藻酸铵。
• ADI（每日允许摄入量）: 未作特殊规定（FAO/WHO, 2001）
• GRAS (GeneRAlly Recognized As Safe): 获得美国FDA的认可，适用于食品工业中的多种用途。

使用限量

• 食品行业：在多种食品中应用广泛，具体使用量依据不同类型的食品而有所不同。
• GB 2760-96: 对于某些特定的食品类型（如胶姆糖）有具体的限制。
• FDA规定: 在不同的食品类别中的最大允许添加比例也有所不同。

生产方法

海藻酸铵的具体生产方法未详细说明，但从其用途和化学性质推测，可能是从天然海带等海洋植物中提取并经过一系列化学处理获得的产品。实际的生产过程可能涉及提取、精制、化学修饰等步骤。

总之，海藻酸铵作为一种多功能添加剂，在多个行业中都有广泛的应用，并且被认为是安全的。

文献信息

• Preparations having a cooling effect
  申请人：Symrise AG

  公开号：US11234450B2

  公开（公告）日：2022-02-01

  Proposed are preparations, comprising special amides and menthol or menthol compounds or aromatic substances, characterized in that they have improved flavor and scent properties, and also that they allow the production of preparations, particularly emulsions with improved shelf life.

  建议的制剂由特殊酰胺和薄荷醇或薄荷醇化合物或芳香物质组成，其特点是它们具有更好的风味和香味特性，还能生产出保质期更长的制剂，特别是乳剂。
• Oral composition
  申请人：Symrise AG

  公开号：EP2842428B1

  公开（公告）日：2018-08-08
• Plant Treatment Compositions and Methods for Their Use
  申请人：Majure Wallace Keith

  公开号：US20120021911A1

  公开（公告）日：2012-01-26

  Plant treatment compositions comprising metal alginate salts and at least one amine compound are useful in the treatment of plants, particularly food crops. The metal alginate salts are found to be highly effective in the absence of herbicides, fungicides and pesticides.
• PASSIVE SOLID TUMOR TARGETING ANTICANCER PRODRUG AND PREPARATION METHOD THEREOF
  申请人：Tang Xiaohai

  公开号：US20120244193A1

  公开（公告）日：2012-09-27

  The invention relates to a passive solid tumor-targeted anticancer prodrug and a preparation method thereof, belonging to the field of antitumor drugs. The preparation method includes the following steps: reacting low molecular weight pectin with Mw of 5,000-45,000 with doxorubicin to obtain a pectin-doxorubicin conjugate with Mw of 100,000-1,000,000, preparing the conjugate into a suspension, and treating the suspension in an ultra-high pressure nano homogenizer to obtain the passive solid tumor-targeted anticancer prodrug with particle size of 100 nm-200 nm and melting point of 220-245°, wherein the pectin and doxorubicin are linked by an amide bond, and the pectin is linked by an ester bond formed by condensing carboxyl groups and hydroxyl groups of pectin molecules. Cell inhibition rate of the anticancer prodrug for humanized lung cancer cells NCI-H446 and A549 is equivalent to that of doxorubicin hydrochloride. In the efficacy research of melanoma B16 pulmonary metastasis model mice, the life span of tumor-bearing mice is 42.3±12.4 days, which is remarkably higher than that of the doxorubicin hydrochloride group (23.1±10.2 days).
• Plant Treatment Compositions and Methods for their Use
  申请人：Bain Oakford George

  公开号：US20130172184A1

  公开（公告）日：2013-07-04

  Plant treatment compositions comprising metal alginate salts and further containing at least one amine compound (sometimes also herein referred to as the “first amine compound”), and additionally includes at least a pH buffer composition comprising a second amine compound (sometimes also herein referred to as the “second amine compound”), which compositions useful in the treatment of plants, particularly food crops. In certain embodiments, the plant treatment compositions are highly effective even wherein the content of metallic copper present is 500 ppm or even less in the plant treatment composition used to treat plants or crops. The plant treatment compositions are found to be highly effective even in the absence of herbicides, fungicides and pesticides.