海藻酸钠

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 海藻酸钠
• 中文别名: 右旋糖酐；海藻酸钠盐；葡聚糖T-70
• 英文名称: Algin
• 英文别名: sodium;(3S,4S,5S,6R)-3,4,5,6-tetrahydroxyoxane-2-carboxylate
• 化学式: C6H9NaO7
• 分子量: 216.12
• InChiKey: MSXHSNHNTORCAW-MPGIDXPLSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -7.46
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  7

ADMET

毒理性

• 相互作用

建议粘性的藻酸盐在胃肠道中移动缓慢，在小肠的特定部位允许增加核黄素的吸收。

Proposed that viscous alginate moves slowly thru GI tract, allowing enhanced riboflavin absorption at specialized sites in small intestine.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

向每天接受2微居里(137)Cs和0.8微居里(90)Sr的大鼠饮食中添加普鲁士蓝、藻酸钠和磷酸钙，可以减少骨肉瘤的数量，增加寿命。

Addition of Prussian Blue, sodium alginate, and calcium orthophosphate to diet of rats receiving daily 2 uCi (137)Cs and 0.8 uCi (90)Sr reduced number of osteosarcomas, increased life length.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

藻酸钠具有减少锶吸收的能力...它还可以降低大鼠体内其他放射性二价金属离子的滞留，其顺序为：钡 > 锶 > 锡 > 镉 > 锰 > 锌 > 汞，其中钡的水平降至对照组的3%，镉和锰的水平在三周内降至约50%。

Sodium alginate has the ability to reduce strontium absorption, ... /it/ can also decrease the retention of other radioactive divalent metallic ions in rats in the following order: Barium > Strontium > Tin > Cadmium > Manganese > Zinc > Mercury, with Barium levels being reduced to 3% of control values and Cadmium and Manganese levels, to about 50% in three weeks.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

两组各12只Sprague-Dawley断奶雄性大鼠分别接受对照饮食或含有10%海藻酸钠的饮食（以玉米淀粉为代价）持续8天。在海藻酸钠组中，粪便干物质显著增加。海藻酸钠对钙和锌的吸收没有影响。铁、铬和钴的吸收在海藻酸钠组中显著降低。

Two groups of 12 male weanling Sprague-Dawley rats received a control diet or a diet with 10% Na-alginate, at the expense of corn starch, for 8 days. A marked increase in fecal dry matter was seen in the alginate group. Ca and Zn absorption were not affected by alginate. Absorption of Fe, Cr, and Co were significantly reduced in the alginate group.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

老鼠被喂食了含有磷酸钙和藻酸钠的常规饲料，这些添加剂被分别和同时添加，持续了4-5个月。在此期间，观察了老鼠的生长速度和一些身体组织的视觉及组织学异常。没有观察到毒性效应。对于同时补充这两种添加剂的老鼠，钙的吸收和骨骼保留几乎没有变化，但锶的吸收和保留减少了7倍。

Rats were fed a stock diet supplemented with calcium phosphate and sodium alginate, both separately and simultaneously, over a period of 4-5 months. Observations were made at intervals on the growth rate and on visual and histological abnormalities in some body tissues. No toxic effects were observed. The absorption and skeletal retention of calcium for rats on the combined supplements remained almost unchanged but the absorption and retention of strontium was reduced 7-fold.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

显然...在摄入时没有显著分解或吸收...

Apparently ... not decomposed or absorbed appreciably when ingested ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

当给予小鼠14C标记的丙二醇海藻酸盐或14C标记的丙二醇海藻酸酯...时，未水解的酯和海藻酸盐残基...从胃肠道未被吸收；但是任何水解的丙二醇...被吸收...代谢并排出...单次剂量...1克/千克...通过粪便排出...5天内...

When propyleneglycol (14)C alginate or (14)C propylene glycol alginate ... dosed to mice, unhydrolyzed ester and alginate residue ... unabsorbed from GI tract; but any hydrolyzed propyleneglycol ... absorbed ... metabolized and eliminated ... single dose ... 1 g/kg ... excreted ... feces ... 5 days ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 在5克/千克的剂量下，标签的痕迹仍然存在于直肠中。从掌状海带制备的藻酸盐在大鼠饮食中占每日饮食量的10%时未被吸收。

... After a dose of 5 g/kg, traces of label were still present in rectum. Alginate prepared from laminaria digitata was unabsorbed by rats fed at a level of 10% of their daily diet.

来源:Hazardous Substances Data Bank (HSDB)