消旋酮异亮氨酸钙 | 66872-75-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 异亮氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 消旋酮异亮氨酸钙
• 中文别名: (+/-)-3-甲基-2-氧代戊酸钙；3-甲基-2-氧代戊酸钙水合物；2,3,4-三甲氧基苯丙烯酸
• CAS: 66872-75-1
• 化学式: C6H10CaO3
• 分子量: 170.22
• InChiKey: PJSMJIFOGLEATM-UHFFFAOYSA-N

物化性质

• 溶解度：
  碱性溶液（微溶）、水（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.31
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918300090

制备方法与用途

用途： 该产品用作溶剂，并作为烷化、酯化和聚合反应的催化剂。99%的产品主要应用于医药领域，而约70%的产品则主要用于电镀行业。

文献信息

• US4076745A
  申请人：——

  公开号：US4076745A

  公开（公告）日：1978-02-28
• US4100160A
  申请人：——

  公开号：US4100160A

  公开（公告）日：1978-07-11
• [EN] A NOVEL PHARMACEUTICAL FORMULATION OF ALPHA KETOANALOGUE OF AMINO ACIDS AND ADDITIONAL AMINO ACIDS FOR TREATMENT OF CHRONIC KIDNEY DISEASE AND METHOD OF PREPARATION THEREOF<br/>[FR] NOUVELLE FORMULATION PHARMACEUTIQUE D'ALPHA CÉTOANALOGUE D'ACIDES AMINÉS ET D'ACIDES AMINÉS SUPPLÉMENTAIRES POUR UN TRAITEMENT D'UNE MALADIE RÉNALE CHRONIQUE ET SON PROCÉDÉ DE PRÉPARATION
  申请人：RPG LIFE SCIENCES LTD

  公开号：WO2012137216A1

  公开（公告）日：2012-10-11

  A novel pharmaceutical formulation of alpha ketoanalogue of amino acids and additional amino acids for treatment of chronic kidney disease and method of preparation thereof The present invention relates to a pharmaceutical formulation having increased in-vitro dissolution, and reduced and controlled degradation under moisture and heat conditions comprising alpha ketoanalogue of amino acids and additional amino acids as active ingredients, and disintegrant, filler and binder, and coated with moisture barrier coating composition, wherein disintegrant is croscarmellose sodium, filler is microcrystalline cellulose and binder is polyvinyl pyrrolidone, and moisture barrier coating composition comprises film former, plasticizer and solubilizing agent, and stabilizer and suspension agent, wherein film former is polyvinyl alcohol, plasticizer and solubilizing agent is soya lecithin, and stabilizer and suspension agent is xanthan gum. In one embodiment, the present invention also relates to a process for preparation of said pharmaceutical formulation.
• [EN] METHOD FOR TASTE/ODOR MASKING OF A PRODUCT FOR CHRONIC KIDNEY DISEASE PATIENTS<br/>[FR] PROCÉDÉ DE MASQUAGE DE GOÛT/D'ODEUR D'UN PRODUIT POUR DES PATIENTS ATTEINTS D'UNE MALADIE RÉNALE CHRONIQUE
  申请人：ATHENION AG

  公开号：WO2020244798A1

  公开（公告）日：2020-12-10

  The present invention relates to a method for taste/odor masking of a product for chronic kidney disease patients, in particular of compositions containing essential amino acids and/or alpha-ketoanalogues of essential amino acids and/or alpha-hydroxyanalogues of essential amino acids, to corresponding pharmaceutical compositions and their nutritional, therapeutic or prophylactic uses. A phosphatidylcholine-based method is disclosed.