2-(2-硝基-苯甲酰基)丙二酸二乙酯 | 106718-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(2-硝基-苯甲酰基)丙二酸二乙酯
• 英文名称: diethyl 2-(2-nitro-benzoyl)malonate
• 英文别名: Diethyl 2-(2-nitrobenzoyl)malonate；diethyl 2-(2-nitrobenzoyl)propanedioate
• CAS: 106718-56-3
• 化学式: C₁₄H₁₅NO₇
• 分子量: 309.276
• InChiKey: LXZPRMYHTALASD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(2-硝基-苯甲酰基)丙二酸二乙酯 在 硫酸 、 溶剂黄146 作用下， 生成 邻硝基苯乙酮
  参考文献：
  名称：

  Synthesis of Methyl Ketones from Diethyl Acylmalonates

  摘要：

  DOI：

  10.1021/ja01211a508
• 作为产物：
  描述：

  2-硝基苯甲酰氯 在 乙醚 、 sodium ethanolate 作用下， 生成 2-(2-硝基-苯甲酰基)丙二酸二乙酯
  参考文献：
  名称：

  Bischoff; Rach, Chemische Berichte, 1884, vol. 17, p. 2781

  摘要：

  DOI：

文献信息

• Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives
  作者：Fan Zhang、Xin Zhai、Li Juan Chen、Jian Guo Qi、Bo Cui、Yu Cheng Gu、Ping Gong

  DOI：10.1016/j.cclet.2011.05.030

  日期：2011.11

  Abstract A series of 2,5-disubstituted pyrimido[5,4- c ]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro . It was found that most of the tested compounds especially compound 17 , shown stronger activity to the selected three cell lines than ZM447439.

  摘要合成了2,5-二取代的嘧啶并[5,4-c]喹啉衍生物，并对其体外对H460，HT-29和MDA-MB-231细胞的杀伤活性进行了评价。发现大多数测试的化合物，特别是化合物17，对所选的三种细胞系显示出比ZM447439更强的活性。
• 2-arylquinolines and process for producing the same
  申请人：Asahi Glass Co., Ltd.

  公开号：US05856337A1

  公开（公告）日：1999-01-05

  2-Arylquinolines represented by formula (1): ##STR1## wherein R.sup.1, R.sup.3 to R.sup.9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or --C.sub.m F.sub.2m+1 ; R.sup.2 represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy, --C.sub.n F.sub.2n+1 or --CH.sub.2 Q, in which Q represents a monovalent organic group obtained by eliminating from an organic compound having --NH-- the hydrogen atom bonded to the nitrogen, or halogen; X represents halogen or hydrogen; Y represents nitro or amino which may be protected with a protecting group; and m and n each represents an integer of from 1 to 6; and processes for producing the 2-arylquinolines.

  2-芳基喹啉的结构式(1)如下：##STR1##其中R.sup.1，R.sup.3到R.sup.9分别表示氢、卤素、较低烷基、环状较低烷基、芳基、芳基烷基、烷氧基或--C.sub.m F.sub.2m+1；R.sup.2表示氢、卤素、较低烷基、环状较低烷基、芳基、芳基烷基、烷氧基、--C.sub.n F.sub.2n+1或--CH.sub.2 Q，其中Q表示通过从具有--NH--的有机化合物中消除与氮结合的氢原子或卤素而获得的一价有机基团；X表示卤素或氢；Y表示可能用保护基保护的硝基或氨基；m和n分别表示1到6的整数；以及生产2-芳基喹啉的方法。
• Enol elimination reactions. Part III. The scope and limitations of eliminations involving enol sulphonates
  作者：E. J. D. Brown、John Harley-Mason

  DOI：10.1039/j39660001390

  日期：——

  Elimination reactions of enol sulphonates have been further studied. The enol sulphonates of p-anisolyl-, 2-furoyl-, and 2-thenoyl-malonic esters readily gave the corresponding propiolic acids on treatment with base, whereas the enol sulphonates of o-, m-, and p-nitrobenzoylmalonic esters gave negligible yields. The enol sulphonates of cyclopropylcarbonylmalonate gave cyclopropylpropiolic acid, while

  烯醇磺酸盐的消除反应已被进一步研究。的烯醇磺酸盐p -anisolyl-，2-糠酰基，2-噻吩甲酰基，丙二酸酯容易介绍了用碱处理相应的丙炔酸，而烯醇磺酸盐ø - ，米- ，和p -nitrobenzoylmalonic酯，得到可忽略的产量。环丙基羰基丙二酸酯的烯醇磺酸盐得到环丙基丙酸，而三氯乙酰基丙二酸酯和富马酰基丙二酸酯的烯醇磺酸盐不产生炔属产物。三苯甲酰基甲烷的烯醇磺酸盐得到苯甲酰基苯基-乙炔。
• [EN] A QUINOLONE COMPOUND IN SOLID FORMS AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSÉ DE QUINOLONE SOUS FORMES SOLIDES ET SES PROCÉDÉS DE PRÉPARATION
  申请人：ZYDUS LIFESCIENCES LTD

  公开号：WO2022195525A1

  公开（公告）日：2022-09-22

  The present invention relates to novel crystalline forms of a quinolone compound of Formula (I). The invention also relates to processes for the preparation crystalline forms of the compound of Formula (I). Further the disclosure provides a process for the preparation of compound of Formula (I), intermediates, impurities and pharmaceutical compositions thereof.

  本发明涉及公式（I）的喹诺酮化合物的新晶体形式。本发明还涉及制备公式（I）化合物的晶体形式的过程。此外，本发明提供了制备公式（I）化合物、中间体、杂质和药物组成物的过程。
• 2-Arylquinolines and process for producing the same
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0786460A2

  公开（公告）日：1997-07-30

  2-Arylquinolines represented by formula (1): wherein R1, R3 to R9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or -CmF2m+1; R2 represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy, CnF2n+1 or -CH2Q, in which Q represents a monovalent organic group obtained by eliminating from an organic compound having -NH- the hydrogen atom bonded to the nitrogen, or halogen; X represents halogen or hydrogen; Y represents nitro or amino which may be protected with a protecting group; and m and n each represents an integer of from 1 to 6; and processes for producing the 2-arylquinolines.

  由式(1)代表的 2-芳基喹啉： 其中 R1、R3 至 R9 各自代表氢、卤素、低级烷基、环状低级烷基、芳基、芳烷基、烷氧基或 -CmF2m+1；R2 代表氢、卤素、低级烷基、环状低级烷基、芳基、芳烷基、烷氧基、CnF2n+1 或 -CH2Q，其中 Q 代表从具有 -NH- 的有机化合物中除去与氮结合的氢原子或卤素而得到的一价有机基团； X代表卤素或氢；Y代表硝基或氨基，可被保护基团保护；m和n各代表1至6的整数；以及生产2-芳基喹啉的工艺。