12-(p-aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenzacridin-11-one | 159146-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 12-(p-aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenzacridin-11-one
• 英文别名: 12-(p-Aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenz[a]acridin-11-one；12-(p-aminophenyl)benzacridinone；12-(4-Aminophenyl)-9,9-dimethyl-8,10-dihydrobenzo[a]acridin-11-one
• CAS: 159146-73-3
• 化学式: C₂₅H₂₂N₂O
• 分子量: 366.462
• InChiKey: FHDYPOHTIZCGHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  3

上下游信息

反应信息

• 作为反应物：
  描述：

  己二酰氯 、 12-(p-aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenzacridin-11-one 以 丙酮 为溶剂， 反应 0.25h， 以97%的产率得到N,N'-bis[4-(9,9-dimethyl-11-oxo-8,10-dihydrobenzo[a]acridin-12-yl)phenyl]hexanediamide
  参考文献：
  名称：

  Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]alkanediamides

  摘要：

  The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00073-2
• 作为产物：
  描述：

  12-(p-nitrophenyl)benzacridin-11-one 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以69%的产率得到12-(p-aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenzacridin-11-one
  参考文献：
  名称：

  Martinez, Roberto; Cortes, Eduardo C.; Salazar, Olivia E., Journal of Heterocyclic Chemistry, 1994, vol. 31, # 4, p. 1061 - 1064

  摘要：

  DOI：

文献信息

• Azo dyes derived from Aminophenylbenzacridinones. VIII
  作者：Roberto Martínez、Paulino Arteaga、Claudia Mancera

  DOI：10.1002/jhet.5570330245

  日期：1996.3

  The preparation of novel azo-dyes from p-aminophenylbenzacridinones is described. The structure of all the products was corroborated by ir, mass spectrometry and 1H-nmr.

  描述了从对氨基苯基苯甲cri啶酮制备新的偶氮染料。红外，质谱和1 H-nmr证实了所有产物的结构。
• Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]alkanediamides
  作者：Roberto Martı́nez、Juan Antonio Cogordan、Claudia Mancera、Ma.Luisa Dı́az

  DOI：10.1016/s0014-827x(00)00073-2

  日期：2000.11

  The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.
• Martinez, Roberto; Cortes, Eduardo C.; Salazar, Olivia E., Journal of Heterocyclic Chemistry, 1994, vol. 31, # 4, p. 1061 - 1064
  作者：Martinez, Roberto、Cortes, Eduardo C.、Salazar, Olivia E.、Linzaga, Irma E.

  DOI：——

  日期：——