N,N'-bis[4-(9,9-dimethyl-11-oxo-8,10-dihydrobenzo[a]acridin-12-yl)phenyl]hexanediamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N'-bis[4-(9,9-dimethyl-11-oxo-8,10-dihydrobenzo[a]acridin-12-yl)phenyl]hexanediamide
• 化学式: C₅₆H₅₀N₄O₄
• 分子量: 843.037
• InChiKey: OXOKNGNQZUPPHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  64
• 可旋转键数：
  9
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  己二酰氯 、 12-(p-aminophenyl)-9,9-dimethyl-8,9,10,11-tetrahydrobenzacridin-11-one 以 丙酮 为溶剂， 反应 0.25h， 以97%的产率得到N,N'-bis[4-(9,9-dimethyl-11-oxo-8,10-dihydrobenzo[a]acridin-12-yl)phenyl]hexanediamide
  参考文献：
  名称：

  Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]alkanediamides

  摘要：

  The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(00)00073-2

文献信息

• Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]alkanediamides
  作者：Roberto Martı́nez、Juan Antonio Cogordan、Claudia Mancera、Ma.Luisa Dı́az

  DOI：10.1016/s0014-827x(00)00073-2

  日期：2000.11

  The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.