2-(4-(3-chloropropoxy)-phenyl)-naphtho[1,2-d]oxazole | 1119680-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-(3-chloropropoxy)-phenyl)-naphtho[1,2-d]oxazole
• 英文别名: 2-[4-(3-Chloropropoxy)phenyl]benzo[e][1,3]benzoxazole
• CAS: 1119680-70-4
• 化学式: C₂₀H₁₆ClNO₂
• 分子量: 337.806
• InChiKey: TXOAFCNPRJCSDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲基丁胺 、 2-(4-(3-chloropropoxy)-phenyl)-naphtho[1,2-d]oxazole 在 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以90%的产率得到butyl-methyl-[3-(4-(naphtho[1,2-d] oxazol-2-yl)phenoxy)-propyl]-amine
  参考文献：
  名称：

  Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

  摘要：

  A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.009
• 作为产物：
  描述：

  4-(naphtho[1,2-d]oxazol-2-yl)phenol 、 1-溴-3-氯丙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 以95%的产率得到2-(4-(3-chloropropoxy)-phenyl)-naphtho[1,2-d]oxazole
  参考文献：
  名称：

  Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

  摘要：

  A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.009

文献信息

• Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities
  作者：Atul Kumar、Pervez Ahmad、Ram Awatar Maurya、A.B. Singh、Arvind K. Srivastava

  DOI：10.1016/j.ejmech.2008.03.009

  日期：2009.1

  A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity. (C) 2008 Elsevier Masson SAS. All rights reserved.