Ethyl 6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-pyridin-2-ylaziridin-1-yl)quinoline-3-carboxylate | 181426-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Ethyl 6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-pyridin-2-ylaziridin-1-yl)quinoline-3-carboxylate
• 英文别名: ethyl 6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-pyridin-2-ylaziridin-1-yl)quinoline-3-carboxylate
• CAS: 181426-94-8
• 化学式: C₂₄H₂₆FN₅O₃
• 分子量: 451.501
• InChiKey: CZWJJZUSFULGSG-UHFFFAOYSA-N

物化性质

• 沸点：
  637.3±65.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  69
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  Ethyl 6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-pyridin-2-ylaziridin-1-yl)quinoline-3-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以65%的产率得到6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-pyridin-2-yl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid
  参考文献：
  名称：

  Synthesis of N-(1-Aziridinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

  摘要：

  A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3-carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)(4) as oxidizing agent.

  DOI：

  10.3987/com-97-7770
• 作为产物：
  描述：

  乙基6,7-二氟-4-氧代-1,4-二氢-3-喹啉羧酸酯 在 lead(IV) acetate 、 O-tosylhydroxylamine 、 potassium carbonate 作用下， 以 吡啶 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 38.0h， 生成 Ethyl 6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-pyridin-2-ylaziridin-1-yl)quinoline-3-carboxylate
  参考文献：
  名称：

  Synthesis of N-(1-Aziridinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

  摘要：

  A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3-carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)(4) as oxidizing agent.

  DOI：

  10.3987/com-97-7770

文献信息

• Synthesis of N-(1-Aziridinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids
  作者：Sándor Bátori、Géza Tímári、András Messmer、Benjámin Podányi、Lelle Vasvárii-Debreczy、István Hermecz

  DOI：10.3987/com-97-7770

  日期：——

  A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3-carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)(4) as oxidizing agent.