1-hydroxy-3-methylcyclohexanecarboxylic acid | 41248-16-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-hydroxy-3-methylcyclohexanecarboxylic acid
• 英文别名: 1-hydroxy-3-methyl-cyclohexane-carboxylic acid-(1)；1-Hydroxy-3-methyl-cyclohexan-carbonsaeure-(1)；1-Hydroxy-3-methyl-cyclohexancarbonsaeure；3-Methyl-cyclohexanol-(1)-carbonsaeure-(1)；1-Oxy-hexahydro-m-toluylsaeure；1-hydroxy-3-methylcyclohexane-1-carboxylic acid
• CAS: 41248-16-2
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: UWYUTQRWZSNRDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-hydroxy-3-methylcyclohexanecarboxylic acid 在 硫酸 作用下， 生成 3-甲基环己酮
  参考文献：
  名称：

  Perkin; Tattersall, Journal of the Chemical Society, 1905, vol. 87, p. 1101

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基环己酮 在 盐酸 、 potassium cyanide 、 sodium hydrogensulfite 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 5.0h， 生成 1-hydroxy-3-methylcyclohexanecarboxylic acid
  参考文献：
  名称：

  Carr, Graham; Whittaker, David, Journal of the Chemical Society. Perkin transactions II, 1987, p. 1877 - 1880

  摘要：

  DOI：

文献信息

• Effects of cosmonaut vestibular training on vestibular function prior to spaceflight
  作者：Gilles Clément、Olivier Deguine、Marc Parant、Marie-Claude Costes-Salon、Pascale Vasseur-Clausen、Anne Pavy-LeTraon

  DOI：10.1007/s004210100494

  日期：2001.10

  The purpose of this study was to quantify the effects of repetitive Coriolis and cross-coupled stimulations, similar to the vestibular training the cosmonauts are exposed to prior to their spaceflight, on vestibular function in control subjects on Earth. Ten volunteers were passively rotated in yaw on a rotating chair while executing standardized pitch head-and-trunk movements. The chair stopped to change direction after 12 head-and-trunk movements were made. The runs were grouped in sessions of ten,which were repeated daily for 10 days. The severity of motion sickness was assessed by subjective judgment and measurements of skin pallor and salivary total protein concentration, and nystagmus was recorded. The severity of motion sickness and nystagmus decreased during cosmonaut vestibular training (CVT). One month after the end of CVT, nystagmus responses were still about 20-30% lower than control values. These results indicate that CVT induces a habituation of vestibular responses. One important implication of this experiment concerns space studies on cosmonauts who are exposed to such vestibular training prior to their spaceflight.
• Aloy; Rabaut, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1913, vol. 156, p. 1548
  作者：Aloy、Rabaut

  DOI：——

  日期：——
• Passerini, Gazzetta Chimica Italiana, 1923, vol. 53, p. 413
  作者：Passerini

  DOI：——

  日期：——
• Perkin; Tattersall, Journal of the Chemical Society, 1905, vol. 87, p. 1091
  作者：Perkin、Tattersall

  DOI：——

  日期：——
• Kamernizkii; Achrem, Zhurnal Obshchei Khimii, 1960, vol. 30, p. 754,757
  作者：Kamernizkii、Achrem

  DOI：——

  日期：——