2-(4-甲氧基苯氧基)丙酸 | 150436-68-3

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 环羧酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-甲氧基苯氧基)丙酸
• 中文别名: 2-(4-甲氧基苯氧基)丙酸钠
• CAS: 150436-68-3
• 化学式: C10H12NaO4
• 分子量: 219.19
• InChiKey: SJQKPPSYZSRKEP-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMF：20mg/mL； DMSO：10mg/mL；乙醇：1mg/mL； PBS（pH 7.2）：10 mg/mL
• LogP：
  1.654 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

制备方法与用途

2-(4-甲氧基苯氧基)丙酸钠是一种甜味抑制剂，存在于咖啡豆中，为一种天然物质。它以白色晶体粉末的形式存在，无味。在受热和焙烤过程中，即使在低pH值条件下也十分稳定，在产品保质期内其抑制甜度的性能保持不变。

文献信息

• Lactose-hydrolyzed milk with suppressed sweetness
  申请人：STERLING WINTHROP INC.

  公开号：EP0558141A1

  公开（公告）日：1993-09-01

  A lactose-hydrolyzed fluid milk comprising fluid milk, the normal lactose content of which has been reduced by at least about 70% by lactase hydrolysis, having incorporated therein from about 1 to about 10 ppm of 2-(4-methoxyphenoxy)propanoic acid or a salt thereof, a method of preparation thereof and a method of suppressing perceived sweetness of lactose-hydrolyzed milk by incorporating 2-(4-methoxyphenoxy)propanoic acid or a salt thereof in the milk.

  一种乳糖水解液态奶，包括通过乳糖酶水解使正常乳糖含量降低至少约 70% 的液态奶，其中掺入了约 1 至约 10 ppm 的 2-（4-甲氧基苯氧基）丙酸或其盐，及其制备方法和通过在奶中掺入 2-（4-甲氧基苯氧基）丙酸或其盐来抑制乳糖水解奶的甜味的方法。
• Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
  申请人：BIORESEARCH, INC.

  公开号：EP0727149A2

  公开（公告）日：1996-08-21

  Sweetness inhibitors which are substantially tasteless have been found to be bitter taste inhibitors or blockers. Conversely, bitter taste inhibitors which are substantially tasteless have been found to be sweet taste inhibitors or blockers.

  已发现基本上无味的甜味抑制剂是苦味抑制剂或阻断剂。反之，基本无味的苦味抑制剂被发现是甜味抑制剂或阻断剂。
• Ingestible containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
  申请人：BIORESEARCH, INC.

  公开号：EP0728419A2

  公开（公告）日：1996-08-28

  Sweetness inhibitors which are substantially tasteless have been found to be bitter taste inhibitors or blockers. Conversely, bitter taste inhibitors which are substantially tasteless have been found to be sweet taste inhibitors or blockers.

  已发现基本上无味的甜味抑制剂是苦味抑制剂或阻断剂。反之，基本无味的苦味抑制剂被发现是甜味抑制剂或阻断剂。
• Use of hydroxyflavanones for masking bitter taste
  申请人：——

  公开号：US20020188019A1

  公开（公告）日：2002-12-12

  The invention relates to hydroxyflavanones, their salts and stereoisomers and their mixtures for suppressing or reducing the bitter and/or metallic taste impression. In addition, the invention relates to nutritional, nutritive or consumable preparations or oral pharmaceutical compositions, characterized in that these have an active content of hydroxyflavanones, their salts and stereoisomers or their mixtures.

  本发明涉及羟基黄烷酮、其盐和立体异构体及其混合物，用于抑制或减轻苦味和/或金属味。此外，本发明还涉及营养型、滋补型或消耗型制剂或口服药物组合物，其特征在于这些制剂或组合物具有羟基黄烷酮、其盐和立体异构体或其混合物的活性成分。
• INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS
  申请人：BIORESEARCH, INC.

  公开号：EP0485587A1

  公开（公告）日：1992-05-20