4-chloro-6,7-dimethoxy-3-quinolinecarboxamide | 476193-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide
• 英文别名: 4-chloro-6,7-dimethoxyquinoline-3-carboxamide；6,7-Dimethoxy-4-chloro-3-quinolinecarboxamide
• CAS: 476193-83-6
• 化学式: C₁₂H₁₁ClN₂O₃
• 分子量: 266.684
• InChiKey: KVFVCKLAWBGEBL-UHFFFAOYSA-N

物化性质

• 沸点：
  436.2±45.0 °C(Predicted)
• 密度：
  1.364±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-6,7-dimethoxy-3-quinolinecarboxamide 、 2,3-二甲基苯胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 4-(2,3-Dimethylphenylamino)-6,7-dimethoxyquinoline-3-carboxamide
  参考文献：
  名称：

  Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

  摘要：

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.046
• 作为产物：
  描述：

  C₁₂H₉Cl₂NO₃ 在 ammonium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 生成 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide
  参考文献：
  名称：

  Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

  摘要：

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.046

文献信息

• Novel 4-anilinoquinoline-3-carboxamides
  申请人：——

  公开号：US20040248923A1

  公开（公告）日：2004-12-09

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.

  本发明涉及公式（IA）的新型化合物，它们是JAK3激酶抑制剂，以及它们的制备方法和包含它们的药物组合物。
• Compounds and methods of use
  申请人：Potashman Michele

  公开号：US20060241115A1

  公开（公告）日：2006-10-26

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗HGF介导的疾病等具有有效性。本发明涵盖了新颖的化合物、类似物、前药和其药学上可接受的盐，以及用于预防和治疗涉及癌症等疾病和其他疾病或状况的药物组合物和方法。该发明还涉及制备此类化合物的过程，以及在此类过程中有用的中间体。
• 4-anilinoquinoline-3-carboxamides
  申请人：AstraZeneca AB

  公开号：US07037925B2

  公开（公告）日：2006-05-02

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.

  本发明涉及一种新型化合物（IA式），它们是JAK3激酶抑制剂，以及它们的制备方法和包含它们的药物组合物。
• NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES
  申请人：AstraZeneca AB

  公开号：EP1387830A1

  公开（公告）日：2004-02-11
• COMPOUNDS AND METHODS OF USE
  申请人：AMGEN INC.

  公开号：EP1713484A2

  公开（公告）日：2006-10-25