溶剂红172 | 512-13-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 溶剂红172
• 中文别名: 1,3,3-三甲基双环[2.2.1]-庚-2-醇
• 英文名称: (-)-α-fenchol
• 英文别名: (1R)-endo-(+)-fenchyl alcohol；endo–fenchol；α-fenchol；β-fenchol；(+)-endo-fenchol；1S,2R,4R-fenchol；alpha-Fenchol；(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol
• CAS: 512-13-0
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: IAIHUHQCLTYTSF-MRTMQBJTSA-N

物化性质

• 熔点：
  43-46 °C
• 沸点：
  201-202 °C(lit.)
• 密度：
  0.9034
• 闪点：
  165 °F
• LogP：
  2.71
• 物理描述：
  White to pale yellow crystals; Camphoraceous aroma
• 溶解度：
  Soluble in vegetable oils; Very slightly soluble in water
• 保留指数：
  1090;1094;1101;1105;1103;1094;1088

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品运输编号：
  UN 1325 4.1/PG 2

反应信息

• 作为反应物：
  描述：

  溶剂红172 在 kaolin 作用下， 生成 1,4,7-trimethyl-norbornan-2-ol
  参考文献：
  名称：

  Toivonen, Suomen Kemistilehti B, 1935, vol. 8, p. 10

  摘要：

  DOI：
• 作为产物：
  描述：

  (+)-葑酮 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以3.9 g的产率得到溶剂红172
  参考文献：
  名称：

  Synthesis and Sweetness Characteristics of l-Aspartyl-d-Alanine Fenchyl Esters

  摘要：

  Four isomers of the L-aspartyl-D-alanine fenchyl esters were prepared as potential peptide sweeteners. L-Aspartyl-D-alanine (+)-alpha -fenchyl ester and L-aspartyl-D-alanine (-)-beta -fenchyl ester showed sweetness with potencies 250 and 160 times higher than that of sucrose, respectively. In contrast, L-aspartyl-D-alanine (+)-beta -fenchyl ester and L-:aspartyl-D-alanine (-)-alpha -fenchyl ester had the highest sweetness potencies at 5700 and 1100 times that of sucrose, respectively. In particular, L-aspartyl-D-alanine (-)-alpha -fenchyl ester had an excellent sweetness quality; but L-,aspartyl-D-alanine (+)-beta -fenchyl ester did not have an excellent quality of sweetness because it displayed an aftertaste caused by the strong sweetness.

  DOI：

  10.1021/jf010344o

文献信息

• Chiral β-lithio enol ethers: Synthesis and properties
  作者：Virginie Godebout、Sandrine Lecomte、Frederic Levasseur、Lucette Duhamel

  DOI：10.1016/0040-4039(96)01662-0

  日期：1996.9

  Chiral lithio enol ethers 1 obtained from corresponding Z-bromo enol ethers react with alkyliodides, acylchlorides, leading to new chiral enol ethers of controlled configuration 5–8.

  从相应的Z-溴烯醇醚获得的手性硫代烯醇醚1与烷基碘化物，酰氯反应，生成5-8可控构型的新手性烯醇醚。
• Terpene Analogues of Dithiophospate Pesticides
  作者：Rafael A. Cherkasov、Artem V. Sofronov、Yevgeniy M. Martianov、Il’yas S. Nizamov、Dmitriy A. Terenzhev

  DOI：10.1080/10426507.2010.514310

  日期：2011.3.31

  Abstract New optically active O,O-diterpenyl dithiophosphoric and O-terpenyl aryldithiophosphonic acids were prepared when chiral terpenols such as (1R)-endo-(+)-fenchyl alcohol, (1S)-endo-(−)-borneol, (1R)-(−)-nopol, and (1R,2S,3S,5R)-(+)-isopinocampheol were involved in reactions with tetraphosphorus decasulfide and 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-disulfides.

  摘要 以(1R)-内-(+)-芴醇、(1S)-内-(-)-冰片醇、(1R)等手性萜醇为原料制备了新型光学活性的O,O-二萜二硫代磷酸和O-萜芳基二硫代膦酸。 )-(-)-nopol 和 (1R,2S,3S,5R)-(+)-isopinocampheol 参与与四硫化四磷和 2,4-二芳基 1,3,2,4-dithiadiphosphetane-2,4 的反应- 二硫化物。
• Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers
  作者：Xia Wang、Yue Tang、Cheng-Yu Long、Wen-Ke Dong、Chenchen Li、Xinhua Xu、Wanxiang Zhao、Xue-Qiang Wang

  DOI：10.1021/acs.orglett.8b01758

  日期：2018.8.17

  A transition-metal-free protocol capable of synthesizing diarylated aniline derivatives is reported. This method could be further employed to prepare aryl alkyl ethers. A wide range of thioethers, anilines, as well as alcohols were tolerated thanks to the mild reaction conditions. The strength of our method was demonstrated by performing a gram-scale reaction (20 mmol) followed by conversion of the

  报道了能够合成二芳基苯胺衍生物的无过渡金属的方案。该方法可以进一步用于制备芳基烷基醚。由于反应条件温和，因此可以耐受多种硫醚，苯胺和醇类。通过进行克级反应（20 mmol），然后将腈基转化为可合成使用的醛，酮和羧酸，证明了我们方法的优势。
• PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE
  申请人：Ley Jakob Peter

  公开号：US20110045069A1

  公开（公告）日：2011-02-24

  A description is given of precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease, in particular for the prevention or treatment of Type 2 diabetes. A description is also given of uses of these precursor compounds and edible compositions, preparations for nutrition or pleasure or semi-finished products and pharmaceutical preparations, containing such precursor compounds.

  描述了甜味受体拮抗剂的前体化合物，用于预防或治疗疾病，特别是用于预防或治疗2型糖尿病。还描述了这些前体化合物的用途，以及包含这些前体化合物的食用组合物、营养或愉悦制剂、半成品和含有这些前体化合物的药物制剂。
• Novel Carboxylic Acid Derivatives
  申请人：Beumer Raphael

  公开号：US20090258887A1

  公开（公告）日：2009-10-15

  The present invention is concerned with novel arylalkyl carboxylic acid derivatives, more specifically, with acylates of arylalkyl carboxylic acids with naturally occurring, non-toxic hydroxy, sulfhydryl, amino or imino compounds, and to compositions containing them. The compositions are preferably cosmetic preparations.

  本发明涉及一种新颖的芳基烷基羧酸衍生物，更具体地说，涉及芳基烷基羧酸的酰化物与天然存在的、无毒的羟基、硫醇、氨基或亚氨基化合物的组合物，以及含有它们的组合物。这些组合物最好是化妆品制剂。