N-hydroacridinium bromide | 37037-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-hydroacridinium bromide
• 英文别名: acridinium hydrobromide；N-acridinium bromide；acridine hydrobromide；Acridin; Hydrobromid；Acridin-10-ium;bromide
• CAS: 37037-42-6
• 化学式: BrH*C₁₃H₉N
• 分子量: 260.133
• InChiKey: WOVFJBGKJQEQQD-UHFFFAOYSA-N

物化性质

• 熔点：
  264 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.97
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-hydroacridinium bromide 在 lithium aluminium tetrahydride 、 双氧水 、 2,3-二氯-5,6-二氰基-1,4-苯醌 、 lithium diisopropyl amide 作用下， 以 alkaline aq. solution 为溶剂， 生成 甲基-蒽酮
  参考文献：
  名称：

  Chemiluminescent Autoxidation of a-Silyl Carbanions Derived from 9-Silyl-10-methylacridanes

  摘要：

  The autoxidation of alpha-silyl carbanions derived from 9-trimethysilyl- and 9-triphenylsilyl-10-methylacridanes (1a and 1b) produced the fluorescent N-methylacridone (NMA) accompanied by weak chemiluminescence. Differences in the chemiluminescence quantum yields and the time course of the light emission were detected between the reactions of la and 1b, which was due to the substituent on the silicon atom. Additionally, the 9-trimethylsilyl-10-methylacridinium salt also underwent a chemiluminescent reaction when reacted with alkaline hydrogen peroxide. It is probable that these chemiluminescent reactions would proceed via the Peterson-type reaction and involve the dioxasiletanide-like species during the reaction pathway.

  DOI：

  10.3987/com-04-10094
• 作为产物：
  描述：

  吖啶 在 氢溴酸 作用下， 以 丙酮 为溶剂， 反应 0.5h， 生成 N-hydroacridinium bromide
  参考文献：
  名称：

  一系列新的同时含有cri啶阳离子和卤素阴离子的二硫代镍镍化合物的合成和表征

  摘要：

  摘要新型的[Ni（dmit）2]-化合物[AcrH] [Ni（dmit）2] [MeOH]（1），[AcrH] 2 [Ni（dmit）2] [Cl]（2），合成了[AcrH] 2 [Ni（dmit）2] [Br]（3）（其中AcrH代表质子化a啶）。所合成的化合物通过ESI-MS，IR，UV-Vis和X射线晶体学表征。我们表明，这些盐的化学组成的微小变化会导致它们的晶体结构和物理性质发生显着差异。与化合物2和3相比，由于较短的S conductivityS距离，化合物1表现出更好的电导率和更强的反铁磁相互作用。由于丰富的分子间相互作用，化合物1可以自组装成高结晶的棒状晶体。

  DOI：

  10.1016/j.ica.2013.10.020

文献信息

• Chemiluminescence in Autoxidation of Phosphonate Carbanions. Phospha-1,2-dioxetanes as the Most Likely High-Energy Intermediates
  作者：Jiro Motoyoshiya、Tsuneaki Ikeda、Shuji Tsuboi、Tatsuya Kusaura、Yoshino Takeuchi、Satoko Hayashi、Sachiko Yoshioka、Yutaka Takaguchi、Hiromu Aoyama

  DOI：10.1021/jo030046l

  日期：2003.7.1

  Autoxidation of the phosphonate carbanions derived from 9-phosphono-10-hydroacridanes provided chemiluminescence ascribed to the excited acridone anion. The intramolecular CIEEL (chemically initiated electron exchange luminescence) mechanism can be applied to this chemiluminescence because of the much higher emission efficiency compared to that of 9-phosphono-10-methylacridanes. The effect of the phosphonate

  衍生自9-膦酰基-10-氢rid啶烷的膦酸酯碳负离子的自氧化作用提供了归因于激发的a啶酮阴离子的化学发光。分子内CIEEL（化学引发的电子交换发光）机制可以应用于这种化学发光，因为与9-膦酰基-10-甲基ac啶相比，其发射效率要高得多。膦酸酯取代基对发光效率的影响，特别是对化学发光衰减速率的影响，可以解释为源自磷原子的化合价偏差，这与取代基对烯烃的烯化反应中几何选择性的影响有关。膦酸碳负离子。在二乙基二苯基甲基膦酸酯和芴基膦酸酯的碳负离子的自氧化中，还检测到在存在荧光团的情况下增强的化学发光。尽管证据是间接的，但这些结果强烈支持以下观点，即1,2-二氧杂环丁烷是最有可能产生激发分子的高能中间体。
• COMPOSITION FOR TREATING OR PREVENTING ATOPIC DERMATITIS
  申请人：Nanoegg Research Laboratories, Inc.

  公开号：EP3456353A1

  公开（公告）日：2019-03-20

  The present invention provides a composition and a method both for treating or preventing atopic dermatitis effectively. Provided is a composition which contains an acetylcholine inhibitor, e.g., an anticholinergic substance, as an active ingredient. Also provided is a method which includes a step of administering an acetylcholine inhibitor such as an anticholinergic substance. The detailed mechanism of the development of atopic dermatitis has not been elucidated so far. Therefore, it has been difficult to treat atopic dermatitis effectively. The composition according to the present invention can treat atopic dermatitis effectively through the inhibition of the action of acetylcholine.

  本发明提供了一种有效治疗或预防特应性皮炎的组合物和方法。本发明提供了一种含有乙酰胆碱抑制剂（如抗胆碱能物质）作为活性成分的组合物。还提供了一种方法，其中包括施用乙酰胆碱抑制剂（如抗胆碱能物质）的步骤。迄今为止，特应性皮炎的详细发病机制尚未阐明。因此，特应性皮炎很难得到有效治疗。根据本发明的组合物可以通过抑制乙酰胆碱的作用有效治疗特应性皮炎。
• Reactions of 9-Phosphorylacridines with Aqueous Hydrogen Peroxide Accompanied by Weak Chemilumine-scence: Remarkable Substituent Effect on Emission Efficiency
  作者：Jiro Motoyoshiya、Rie Shima、Yutaka Takaguchi、Yoshinori Nishii、Hiromu Aoyama

  DOI：10.3987/com-03-9871

  日期：——

  The reaction of 9-phosphorylacridines with aqueous hydrogen peroxide provides weak chemiluminescence, whose emission efficiency depends on the structures of the phosphorus groups. The bulky substituents in the phosphorus groups increased the chemiluminescence quantum yields, which can be explained by assuming that the present chemiluminescence reaction involves a CIEEL process via phospha-1,2-dioxetanes as the high-energy intermediates.
• MAGER S.; HORN M.; HOPARTEAN I.; MOTIU A., MONATSH. CHEM., 1978, 109, NO 6, 1403-1412
  作者：MAGER S.、 HORN M.、 HOPARTEAN I.、 MOTIU A.

  DOI：——

  日期：——
• ENHANCED BONE CELLS GROWTH AND PROLIFERATION ON TiO2 NANOTUBULAR SUBSTRATES TREATED BY RADIO-FREQUENCY PLASMA DISCHARGE
  申请人：Biris Alexandru S.

  公开号：US20110236435A1

  公开（公告）日：2011-09-29

  A method for growing bone cells. In one aspect, the present invention provides a method for growing bone cells, comprising the steps of (a) anodizing a titanium substrate to form an array of titanium dioxide nanotubes on a surface of the titanium substrate, (b) subjecting the anodized titanium substrate to a radio frequency plasma discharge to chemically modify the array of titanium dioxide nanotubes formed on the surface of the titanium substrate, (c) seeding bone cells onto the surface of the titanium substrate that has an array of titanium dioxide nanotubes thereon after the subjecting step, and (d) incubating the seeded bone cells for a period of time effective for the cells to grow and proliferate.