2,6,7,8-tetrahydro-2,2,7,7-tetramethyl-1-phenylquinolin-5(1H)-one | 1402906-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,6,7,8-tetrahydro-2,2,7,7-tetramethyl-1-phenylquinolin-5(1H)-one
• 英文别名: 2,6,7,8-Tetrahydro-2,2,7,7-tetramethyl-1-phenylquinolin-5(1h)-one；2,2,7,7-tetramethyl-1-phenyl-6,8-dihydroquinolin-5-one
• CAS: 1402906-98-2
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: FPDJPIINEHLOSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲基-2-丁烯醛 、 3-苯胺基-5,5-二甲基环己-2-烯-1-酮 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以90%的产率得到2,6,7,8-tetrahydro-2,2,7,7-tetramethyl-1-phenylquinolin-5(1H)-one
  参考文献：
  名称：

  Efficient synthesis of tetrahydroquinolinones by acetic acid-mediated formal [3+3] cycloaddition

  摘要：

  A simple and efficient method to synthesize a variety of tetrahydroquinolinones was successfully achieved by reacting various beta-enaminones with several alpha,beta-unsaturated aldehydes. This strategy can be viewed as a Bronsted acid-mediated formal [3+3] cycloaddition.

  DOI：

  10.1007/s00706-012-0762-0

文献信息

• Efficient synthesis of tetrahydroquinolinones by acetic acid-mediated formal [3+3] cycloaddition
  作者：Quang Huy To、Yong Rok Lee、Sung Hong Kim

  DOI：10.1007/s00706-012-0762-0

  日期：2012.10

  A simple and efficient method to synthesize a variety of tetrahydroquinolinones was successfully achieved by reacting various beta-enaminones with several alpha,beta-unsaturated aldehydes. This strategy can be viewed as a Bronsted acid-mediated formal [3+3] cycloaddition.