(R)-2-((2Z,4Z,6Z)-cyclohepta-2,4,6-trienyl)butan-1-ol | 1365647-06-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (R)-2-((2Z,4Z,6Z)-cyclohepta-2,4,6-trienyl)butan-1-ol
• 英文别名: (2R)-2-cyclohepta-2,4,6-trien-1-ylbutan-1-ol
• CAS: 1365647-06-8
• 化学式: C₁₁H₁₆O
• 分子量: 164.247
• InChiKey: ZUFITODNPVLKEA-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  tropylium hexafluorophosphate 在 S-α,α-双(3,5-二三氟甲基苯基)脯氨醇三甲基硅醚 、 4-二甲氨基吡啶 、 sodium tetrahydroborate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 24.5h， 生成 (R)-2-((2Z,4Z,6Z)-cyclohepta-2,4,6-trienyl)butan-1-ol
  参考文献：
  名称：

  Organocatalytic Asymmetric 1,4-Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether

  摘要：

  The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82-96%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular alpha-alkylation of aldehydes with acridiniums salt.

  DOI：

  10.1021/jo2025114

文献信息

• Organocatalytic Enantioselective Dehydrogenative<i>α</i>-Alkylation of Aldehydes with Benzylic Compounds
  作者：Fen Huang、Lubin Xu、Jian Xiao

  DOI：10.1002/cjoc.201200850

  日期：2012.11

  The highly enantioselective cross‐dehydrogenative coupling of aldehydes with benzylic compounds has been developed as an efficient and rapid protocol for synthesis of enantioriched α‐alkylated aldehydes.

  醛与苄基化合物的高度对映选择性的交叉脱氢偶联已被开发为合成对映异构的α-烷基化醛的一种有效且快速的方法。
• Organocatalytic Asymmetric 1,4-Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether
  作者：Tao Liang、Jian Xiao、Zhiyi Xiong、Xingwei Li

  DOI：10.1021/jo2025114

  日期：2012.4.6

  The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82-96%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular alpha-alkylation of aldehydes with acridiniums salt.