| 1280200-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• CAS: 1280200-05-6
• 化学式: C₇H₈O₂
• 分子量: 124.139
• InChiKey: LNKHGHZUAAHZLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  、 色酮-3-甲醛 在 三丁基膦 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 邻二氯苯 为溶剂， 反应 0.17h， 生成 1,2-Dihydropyrano[4,3-a]xanthene-4,12-dione
  参考文献：
  名称：

  Natural Product Biosynthesis Inspired Concise and Stereoselective Synthesis of Benzopyrones and Related Scaffolds

  摘要：

  A natural product biosynthesis-inspired strategy to explore biologically relevant chemical space is presented. A phosphine-catalyzed cascade and stereoselective annulation provides a common tricyclic benzopyrone intermediate that was efficiently transformed into diverse and related naturally occurring scaffolds.

  DOI：

  10.1021/ol200389p
• 作为产物：
  描述：

  delta-戊内酯 在 溴 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 23.84h， 生成
  参考文献：
  名称：

  Natural Product Biosynthesis Inspired Concise and Stereoselective Synthesis of Benzopyrones and Related Scaffolds

  摘要：

  A natural product biosynthesis-inspired strategy to explore biologically relevant chemical space is presented. A phosphine-catalyzed cascade and stereoselective annulation provides a common tricyclic benzopyrone intermediate that was efficiently transformed into diverse and related naturally occurring scaffolds.

  DOI：

  10.1021/ol200389p

文献信息

• Natural Product Biosynthesis Inspired Concise and Stereoselective Synthesis of Benzopyrones and Related Scaffolds
  作者：Baburaj Baskar、Pierre-Yves Dakas、Kamal Kumar

  DOI：10.1021/ol200389p

  日期：2011.4.15

  A natural product biosynthesis-inspired strategy to explore biologically relevant chemical space is presented. A phosphine-catalyzed cascade and stereoselective annulation provides a common tricyclic benzopyrone intermediate that was efficiently transformed into diverse and related naturally occurring scaffolds.