6-methoxy-2-phenyl-3,4-dipropylquinoline | 1017572-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-2-phenyl-3,4-dipropylquinoline
• 英文别名: 6-Methoxy-2-phenyl-3,4-dipropylquinoline
• CAS: 1017572-98-3
• 化学式: C₂₂H₂₅NO
• 分子量: 319.447
• InChiKey: DETBCJWIWOUSGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-辛炔 、 三氟甲磺酸酐 、 N-茴香酰胺 在 三苯基氧化膦 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以42%的产率得到5-((4-methoxyphenylimino)(phenyl)methyl)oct-4-en-4-yl trifluoromethanesulfonate
  参考文献：
  名称：

  Metal-free synthesis of alkynyl imines using an oxophosphonium-mediated approach at ambient temperatures

  摘要：

  A metal-free approach was developed for the mild synthesis of N-aryl alpha-alkynyl imines from corresponding amide precursors for the first time. The electronic effects of substrates and the reaction mechanisms were investigated and discussed. This newly developed oxophosphonium-triggered one-pot multiple-step method presents the advantages of mild conditions, ease of operation and satisfactory efficiency. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.024

文献信息

• Metal-free synthesis of alkynyl imines using an oxophosphonium-mediated approach at ambient temperatures
  作者：Qing-Li Dong、Guan-Sai Liu、Hai-Bin Zhou、Lin Chen、Zhu-Jun Yao

  DOI：10.1016/j.tetlet.2008.01.024

  日期：2008.3

  A metal-free approach was developed for the mild synthesis of N-aryl alpha-alkynyl imines from corresponding amide precursors for the first time. The electronic effects of substrates and the reaction mechanisms were investigated and discussed. This newly developed oxophosphonium-triggered one-pot multiple-step method presents the advantages of mild conditions, ease of operation and satisfactory efficiency. (c) 2008 Elsevier Ltd. All rights reserved.