4-(6-methoxy-2-phenylquinazolin-4-yl)morpholine | 27414-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(6-methoxy-2-phenylquinazolin-4-yl)morpholine
• 英文别名: 6-methoxy-4-morpholin-4-yl-2-phenyl-quinazoline；2-Phenyl-4-morpholino-6-methoxychinazolin；6-Methoxy-4-morpholino-2-phenylquinazoline
• CAS: 27414-19-3
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: AHICLFURCBDIJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  47.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(6-methoxy-2-phenylquinazolin-4-yl)morpholine 在 三氯化铝 作用下， 以 xylene 为溶剂， 反应 5.0h， 生成 4-morpholin-4-yl-2-phenyl-quinazolin-6-ol
  参考文献：
  名称：

  Synthesis of substituted 2-phenyl-6-hydroxyquinazolines

  摘要：

  DOI：

  10.1007/bf00944430
• 作为产物：
  描述：

  4-吗琳甲腈 、 N-茴香酰胺 在 2-氯吡啶 、 三氟甲磺酸酐 作用下， 以 二氯甲烷 为溶剂， 以79%的产率得到4-(6-methoxy-2-phenylquinazolin-4-yl)morpholine
  参考文献：
  名称：

  Synthesis of Densely Substituted Pyrimidine Derivatives

  摘要：

  The direct condensation of cyanic acid derivatives with N-vinyl/aryl amides affords the corresponding C4-hetcroatom substituted pyrimidines. The use of cyanic bromide and thiocynatomethane in this chemistry provides versatile azaheterocycles poised for further derivatization. The synthesis of a variety of previously inaccessible C2- and C4-pyrimidine derivatives using this methodology is described.

  DOI：

  10.1021/jo9017149

文献信息

• CONDENSED HETEROARYL DERIVATIVES
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1277738A1

  公开（公告）日：2003-01-22

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• Fused heteroaryl derivatives
  申请人：——

  公开号：US20020151544A1

  公开（公告）日：2002-10-17

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• Fused heterolaryl derivatives
  申请人：Hayakawa Masahiko

  公开号：US20060058321A1

  公开（公告）日：2006-03-16

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• FUSED HETEROARYL DERIVATIVES
  申请人：HAYAKAWA Masahiko

  公开号：US20100137584A1

  公开（公告）日：2010-06-03

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
• US6608053B2
  申请人：——

  公开号：US6608053B2

  公开（公告）日：2003-08-19