(Z)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-2-ol | 188957-28-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (Z)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-2-ol
• CAS: 188957-28-0
• 化学式: C₁₇H₂₈O₂Si
• 分子量: 292.494
• InChiKey: MWBULPAIDNQBJP-QXMHVHEDSA-N

物化性质

• 沸点：
  363.0±30.0 °C(Predicted)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.85
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (Z)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-2-ol 在 间氯过氧苯甲酸 、 cesium fluoride 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 10.0h， 生成 3-[(2R,3R)-3-(2-hydroxypropan-2-yl)oxiran-2-yl]phenol
  参考文献：
  名称：

  The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

  摘要：

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00008-2
• 作为产物：
  描述：

  3-碘苯酚 在 Lindlar's catalyst 咪唑 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 氢气 、 二异丙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 34.0h， 生成 (Z)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-methyl-but-3-en-2-ol
  参考文献：
  名称：

  The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

  摘要：

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00008-2

文献信息

• The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation
  作者：Andrew Pelter、Amjad Hussain、Gareth Smith、Robert S Ward

  DOI：10.1016/s0040-4020(97)00008-2

  日期：1997.3

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.