3-(3-methoxyphenoxy)pyridine | 73617-12-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(3-methoxyphenoxy)pyridine
• CAS: 73617-12-6
• 化学式: C₁₂H₁₁NO₂
• 分子量: 201.225
• InChiKey: JUGNWSFUTYKWTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-methoxyphenoxy)pyridine 在 bis-triphenylphosphine-palladium(II) chloride 、 palladium on activated charcoal 、 甲酸铵 、 溶剂黄146 、 间氯过氧苯甲酸 、 silver(l) oxide 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 36.67h， 生成 7-methoxybenzofuro[3,2-b]pyridine
  参考文献：
  名称：

  Synthesis of Benzofuro[3,2-b]pyridines via Palladium-Catalyzed Dual C–H Activation of 3-Phenoxypyridine 1-Oxides

  摘要：

  An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.

  DOI：

  10.1021/ol5033464
• 作为产物：
  描述：

  3-溴吡啶 、 3-甲氧基苯酚 在 copper(l) iodide 、 2,2,6,6-四甲基-3,5-庚二酮 、 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 生成 3-(3-methoxyphenoxy)pyridine
  参考文献：
  名称：

  Synthesis of Benzofuro[3,2-b]pyridines via Palladium-Catalyzed Dual C–H Activation of 3-Phenoxypyridine 1-Oxides

  摘要：

  An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.

  DOI：

  10.1021/ol5033464

文献信息

• 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds
  申请人：Warner-Lambert Company

  公开号：US04187379A1

  公开（公告）日：1980-02-05

  3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, are disclosed. The compounds can be produced by oxidizing a 3-aryloxy-2-pyridinecarbonitrile.

  本发明公开了一种有用于药理学代理的3-芳氧基-2-吡啶碳腈1-氧化物化合物，特别是用于逆转遗忘症的代理。该化合物可以通过氧化3-芳氧基-2-吡啶碳腈来制备。
• 3-(3-Substituted aryloxy)-2-yridinecarbonitriles, pharmaceutical
  申请人：Warner-Lambert Company

  公开号：US04229457A1

  公开（公告）日：1980-10-21

  New 3-(3-methoxyphenoxy)-2-pyridinecarbonitriles, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. Other known 3-(3-substituted phenoxy)-2-pyridinecarbonitriles are disclosed having the same utility. The compounds can be produced by dehydrating the appropriately substituted oxime or displacing an alkoxy group to give the desired carbonitrile.

  本发明公开了新的3-(3-甲氧基苯氧基)-2-吡啶羧腈类化合物，它们可作为药物，特别是作为治疗老年痴呆和逆转遗忘症的药物。还公开了其他已知的3-(3-取代苯氧基)-2-吡啶羧腈类化合物，具有相同的用途。这些化合物可以通过脱水适当取代的肟或置换烷氧基来得到所需的羧腈类化合物。
• US4187379A
  申请人：——

  公开号：US4187379A

  公开（公告）日：1980-02-05
• US4229457A
  申请人：——

  公开号：US4229457A

  公开（公告）日：1980-10-21
• Synthesis of Benzofuro[3,2-<i>b</i>]pyridines via Palladium-Catalyzed Dual C–H Activation of 3-Phenoxypyridine 1-Oxides
  作者：Wei Sun、Min Wang、Yicheng Zhang、Lei Wang

  DOI：10.1021/ol5033464

  日期：2015.2.6

  An efficient oxidative cyclization to straightforward synthesis of benzofuro[3,2-b]pyridine 1-oxides with high regioselectivity via Pd-catalyzed intramolecular dual C-H activation was developed. The resulting products could be deoxygenated easily to the corresponding benzofuro[3,2-b]pyridines in excellent yields.