3-Iod-7-methoxy-4-(3-methoxyphenoxy)-1-methyl-2(1H)-chinolon | 125879-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Iod-7-methoxy-4-(3-methoxyphenoxy)-1-methyl-2(1H)-chinolon
• 英文别名: 3-Iodo-7-methoxy-4-(3-methoxyphenoxy)-1-methylquinolin-2-one
• CAS: 125879-23-4
• 化学式: C₁₈H₁₆INO₄
• 分子量: 437.234
• InChiKey: FDZUMUIOINIKEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Iod-7-methoxy-4-(3-methoxyphenoxy)-1-methyl-2(1H)-chinolon 在 palladium dichloride 三乙胺 作用下， 反应 24.0h， 以65%的产率得到3,9-Dimethoxy-5-methylbenzofuro<3,2-c>chinolin-6(5H)-on
  参考文献：
  名称：

  Stadlbauer, Wolfgang; Laschober, Rita; Kappe, Thomas, Liebigs Annalen der Chemie, 1990, # 6, p. 531 - 539

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲基-3-甲氧基苯胺 在 sodium carbonate 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 3-Iod-7-methoxy-4-(3-methoxyphenoxy)-1-methyl-2(1H)-chinolon
  参考文献：
  名称：

  Stadlbauer, Wolfgang; Laschober, Rita; Kappe, Thomas, Liebigs Annalen der Chemie, 1990, # 6, p. 531 - 539

  摘要：

  DOI：

文献信息

• Pyridinone and pyridinethione derivatives having hiv inhibiting properties
  申请人：——

  公开号：US20040229847A1

  公开（公告）日：2004-11-18

  The present invention is concerned among others with compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C 1-6 alkyl or C 2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R 1 is aryl; R 2 is selected from formyl; C 1-6 alkyloxycarbonylalkyl; Het 2 ; Het 2 C 1-6 alkyl, C 1-6 alkylthio; C 1-6 alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R 3 is selected from formyl; C 1-6 alkyl optionally substituted with one or two C 1-6 alkyloxy; R 1 is hydrogen, with HTV inhibiting properties. 1

  本发明涉及式(I)的化合物，其N-氧化物，药学上可接受的加成盐，季铵盐和立体化学异构体形式，其中Q是卤素，C1-6烷基或C2-6烯基; X为(a-2)，其中q和r为O，Z为O，S或SO; R1为芳基; R2选自甲酰基; C1-6烷氧羰基烷基; Het2; Het2C1-6烷基，C1-6烷基硫醚; C1-6烷基，可选用一个或两个取代基，独立地选自羟基和卤素; R3选自甲酰基; C1-6烷基，可选用一个或两个C1-6烷氧基; R1为氢，具有HTV抑制性能。
• PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES
  申请人：CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP1318995A2

  公开（公告）日：2003-06-18
• US7115608B2
  申请人：——

  公开号：US7115608B2

  公开（公告）日：2006-10-03
• [EN] PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES<br/>[FR] DERIVES DE PYRIDINONE ET DE PYRIDINETHIONE PRESENTANT DES PROPRIETES INHIBITRICES DU VIH
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2002024650A2

  公开（公告）日：2002-03-28

  The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R1 is aryl; R2 is selected from formyl; C1-6alkyloxycarbonylalkyl; Het?2; Het2C¿1-6alkyl, C1-6alkylthio; C1-6alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R3 is selected from formyl; C1-6alkyl optionally substituted with one or two C1-6alkyloxy; R4 is hydrogen, with HIV inhibiting properties.
• Stadlbauer, Wolfgang; Laschober, Rita; Kappe, Thomas, Liebigs Annalen der Chemie, 1990, # 6, p. 531 - 539
  作者：Stadlbauer, Wolfgang、Laschober, Rita、Kappe, Thomas

  DOI：——

  日期：——