2-[2-(2-乙基己氧基)乙氧基]乙醇 | 19327-37-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[2-(2-乙基己氧基)乙氧基]乙醇
• 中文别名: n-辛基-二氧乙烯
• 英文名称: diethylene glycol octyl ether
• 英文别名: octyldiglycol；2-(2-octyloxy-ethoxy)-ethanol；O-Octyl-diaethylenglykol；2-(2-Octyloxy-aethoxy)-aethanol；diethylene glycol monooctyl ether；2-(2-n-octyloxyethoxy)ethanol；n-octyl diglycol；2-(2-Octoxyethoxy)ethanol
• CAS: 19327-37-8
• 化学式: C₁₂H₂₆O₃
• mdl: MFCD00043069
• 分子量: 218.337
• InChiKey: NDSYZZUVPRGESW-UHFFFAOYSA-N

物化性质

• 沸点：
  102 °C (0.4 mmHg)
• 密度：
  0.919 g/mL at 20 °C(lit.)
• 闪点：
  136 °C
• 保留指数：
  1568;1608

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R19,R36/38
• WGK Germany：
  3
• 海关编码：
  2909499000
• 安全说明：
  S24/25,S28

SDS

Name:	N-Octyl-Dioxyethylene Material Safety Data Sheet
Synonym:	Diethylene Glycol Monooctyl Ether; C8E
CAS:	19327-37-8

Section 1 - Chemical Product MSDS Name:N-Octyl-Dioxyethylene Material Safety Data Sheet
Synonym:Diethylene Glycol Monooctyl Ether; C8E

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
19327-37-8	N-Octyl-Dioxyethylene	ca 100	unlisted

Hazard Symbols: XI
Risk Phrases: 19 36/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
May form explosive peroxides. Irritating to eyes and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. May form explosive peroxides. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Isolate area and deny entry. Provide ventilation. Place under an inert atmosphere.

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Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse. If peroxide formation is suspected, do not open or move container. Avoid contact with air and sunlight. Unused chemicals should not be returned to the container. Do not distill since this removes peroxide-inhibitors.
Storage:
Do not store in direct sunlight. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20C). Regularly check inhibitor levels to maintain peroxide levels below 1%. Do not break the seal on the container until it is needed. Label the container with the date it was first opened.
Long-term storage is not recommended.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 19327-37-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear almost colorless
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 102 deg C @ .40mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 136 deg C ( 276.80 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density: .9170g/cm3
Molecular Formula: C12H26O3
Molecular Weight: 218.30

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
On long term storage, substances with similar functional groups form explosive peroxides. Explosive peroxides may form on concentration.
Peroxides can be detonated by friction, impact, or heating. Tends to form explosive peroxides; especially when anhydrous. Peroxide formation may occur in containers that have been opened and remain in storage.
Conditions to Avoid:
Incompatible materials, exposure to air, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 19327-37-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Octyl-Dioxyethylene - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 19 May form explosive peroxides.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 19327-37-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 19327-37-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 19327-37-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-[2-(2-乙基己氧基)乙氧基]乙醇 在 boron trifluoride diacetate 作用下， 生成 四聚乙二醇单辛醚
  参考文献：
  名称：

  Chakhovskoy et al., Bulletin des Societes Chimiques Belges, 1956, vol. 65, p. 453,470

  摘要：

  DOI：
• 作为产物：
  描述：

  环氧乙烷 、 辛醇 在 sodium methylate 作用下， 反应 5.0h， 生成 2-[2-(2-乙基己氧基)乙氧基]乙醇
  参考文献：
  名称：

  一种高效混凝土稳泡剂及其制备方法

  摘要：

  本发明公开了一种高效混凝土稳泡剂及其制备方法，所述高效稳泡剂由多元醇通过酯化反应形成酯键连接两亲性侧链，所述两亲性侧链有3‑7条；所述两亲性侧链一端为疏水链段，一端为亲水单元；其中疏水链段为8~14个碳的烷基链（R），亲水单元为2~10个环氧乙烷单元。所述高效混凝土稳泡剂是一种多链型表面活性剂，所述多链型表面活性剂在碱性条件下水解释放出引气型表面活性剂。本发明所述高效混凝土稳泡剂具有优异的稳定混凝土含气量的效果，同时使硬化混凝土具有较优的气孔结构，并且不会对混凝土的硬化强度产生较大的影响。

  公开号：

  CN113121351B

文献信息

• Topical Mosquito Repellents VII: Alkyl Triethylene Glycol Monoethers
  作者：H. Johnson、J. Degraw、J. Engstrom、W.A. Skinnerx、V.H. Brown、D. Skidmore、H.I. Maibach

  DOI：10.1002/jps.2600640428

  日期：1975.4

  Normal and branched-chain aliphatic monoethers of triethylene glycol are effective topical mosquito repellents. In terms of duration of protection, they are generally superior to the corresponding diethylene glycol analogs and some are superior to diethyltoluamide. The n-heptyl monoether of triethylene glycol affords double the protection time of diethyltoluamide under controlled laboratory conditions

  三甘醇的正链和支链脂族单醚是有效的局部驱蚊剂。就保护的持续时间而言，它们通常优于相应的二甘醇类似物，并且一些优于二乙基甲苯酰胺。三乙二醇的正庚基单醚在受控实验室条件下提供了两倍的二乙基甲苯酰胺保护时间，并且似乎是一种有用的新型驱蚊剂。
• Molecular design of the electron-donating sidearm of lariat ethers: effective coordination of the quinoline moiety in complexation toward alkali-metal cations
  作者：Yohji. Nakatsuji、Tetsuya. Nakamura、Masayuki. Yonetani、Hajime. Yuya、Mitsuo. Okahara

  DOI：10.1021/ja00210a037

  日期：1988.1

  La propriete de coordination specifique du reste quinoleine (bras lateral du lariat) est etudiee en mesurant l'aptitude complexante dans le methanol a 25°C

  La propriete de Coordination specifique du reste quinoleine (braslateral du lariat) est etudiee en mesurant l'aptitude complexante dans le甲醇 a 25°C
• Chain-length dependent conformational behaviour of triblock oligomers α-octyl-ω-n-alkoxytetrakis(oxyethylene)s in the solid state studied by Raman spectroscopy
  作者：Koichi fukuhara、Sei Masatoki、Takeshi Yonemitsu、Hiroatsu Matsuura

  DOI：10.1016/s0022-2860(97)00317-7

  日期：1998.3

  Abstract The Raman spectra of triblock oligomers α-octyl-ω-n-alkoxytetrakis(oxyethylene)s, H(CH2)8(OCH2CH2)4O(CH2)nH with n = 2–7, were measured in the solid state, and the conformational behaviour with changing alkyl chain length was examined. The molecular conformations of these compounds were determined by spectral analysis based on normal coordinate calculations. The conformation changes from the

  摘要 三嵌段低聚物 α-辛基-ω-n-烷氧基四(氧乙烯)s, H(CH2)8(OCH2CH2)4O(CH2)nH（n = 2-7）的拉曼光谱是在固态下测量的，并且检查了改变烷基链长度的构象行为。这些化合物的分子构象是通过基于法向坐标计算的光谱分析确定的。随着烷基链长度 (n) 的增加，构象从延伸/螺旋/延伸形式变为完全延伸形式。氧乙烯链的延伸结构稳定在 n ≥ 3。该实验发现表明，三嵌段化合物中氧乙烯嵌段的延伸结构由长度与氧乙烯嵌段相当或更长的末端烷基嵌段稳定. 这项研究的结果，
• Ceria supported gold–platinum catalysts for the selective oxidation of alkyl ethoxylates
  作者：Katharina Heidkamp、Memet Aytemir、Klaus-Dieter Vorlop、Ulf Prüße

  DOI：10.1039/c3cy00252g

  日期：——

  of a ceria based AuPt catalyst for the selective aerobic oxidation of alkyl ethoxylates to their corresponding carboxylic acids. By optimizing metal loading and the Au to Pt ratio the activity of the catalyst could be increased significantly, while maintaining total selectivity. Although the choice of ceria as a support helped to suppress intermediate metal leaching, the catalyst still showed poor long-term

  这项工作涵盖了基于二氧化铈的AuPt催化剂的开发，该催化剂用于将烷基乙氧基化物选择性好氧氧化为其相应的羧酸。通过优化金属负载量和Au / Pt比，可以在保持总选择性的同时显着提高催化剂的活性。尽管选择二氧化铈作为载体有助于抑制中间金属的浸出，但该催化剂在重复批处理中仍显示出较差的长期稳定性。TPR研究最终可以将失活的原因确定为过氧化。通过连续模式的长期稳定性研究证实了这些怀疑。事实证明，通过采用不利的氧化反应条件，有可能使催化剂失活，即低底物浓度和过量氧气。通过在连续流模式或重复批次中避免这种不利条件，催化剂的长期稳定性大大提高。各种乙氧基化物的底物筛选表明，该催化剂非常适合选择性氧化多种烷基乙氧基化物。
• Surface Activity of Alkoxy Ethoxyethyl β-<scp>d</scp>-Glucopyranosides
  作者：Yulin Fan、Fang Fu、Langqiu Chen、Jiping Li、Jing Zhang

  DOI：10.1021/acs.jafc.9b05966

  日期：2020.3.4

  length. Hexadecoxy ethoxyethyl β-d-glucopyranoside had no water solubility at 25 °C. Decoxy ethoxyethyl β-d-glucopyranoside had the best emulsifying property in the toluene/water and n-octane/water systems and the strongest foaming property, whereas dodecoxy ethoxyethyl β-d-glucopyranoside had the best emulsifying property in the rapeseed oil/water system. Such β-d-glucopyranosides (n = 6-12) exhibited

  将二氧乙烯片段（-（OCH2CH2）2-）引入传统的烷基β-d-吡喃葡萄糖苷中以改善水溶性，并引入了八种非离子表面活性剂，即烷基链长为（n = 6-的烷氧基乙氧基乙基β-d-吡喃葡萄糖苷）。 16），进行了合成和表征。随着烷基链长度的增加，它们的亲水和亲脂平衡值，水溶性，临界胶束浓度（cmc），γcmc，Γmax和吸湿率降低。十六烷氧基乙氧基乙基β-d-吡喃葡萄糖苷在25℃下没有水溶性。脱氧乙氧基乙基β-d-吡喃葡萄糖苷在甲苯/水和正辛烷/水体系中具有最好的乳化性能和最强的起泡性能，而十二烷氧基乙基β-d-吡喃葡萄糖苷在菜籽油/水系统中具有最好的乳化性能。这种β-d-吡喃葡萄糖苷（n = 6-12）表现出优异的表面活性。此外，对于烷氧基乙氧基乙基β-d-吡喃葡萄糖苷（n = 8、10、12）和十二烷基硫酸钠或十六烷基三甲基氯化铵的二元混合物，其cmc值低于纯β-d-吡喃葡萄糖苷。他们具有协