(E)-1-(4-methoxyphenyl)non-1-en-3-one | 74975-53-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-1-(4-methoxyphenyl)non-1-en-3-one
• 英文别名: 1-(4-methoxy-phenyl)-non-1-en-3-one；1-(4-Methoxy-phenyl)-non-1-en-3-on
• CAS: 74975-53-4
• 化学式: C₁₆H₂₂O₂
• 分子量: 246.349
• InChiKey: ROONRUUQJRGHNB-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-1-(4-methoxyphenyl)non-1-en-3-one 、 乙硫醇 以 水 、 乙腈 为溶剂， 生成 1-Ethylsulfanyl-1-(4-methoxy-phenyl)-nonan-3-one
  参考文献：
  名称：

  Dimmock, J.R.; Smith, L.M.; Smith, P.J., Canadian Journal of Chemistry, 1980, vol. 58, p. 984 - 991

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 仲辛酮 在 丙二酸环(亚)异丙酯 、 N,N-二甲基乙二胺 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以60%的产率得到(E)-1-(4-methoxyphenyl)non-1-en-3-one
  参考文献：
  名称：

  通过双协同催化作用获得α，β-不饱和酮

  摘要：

  描述了合成α，β-不饱和酮的双重协同有机催化方法。一锅转换是通过多米诺Knoevenagel-Michael-复古Michael反应序列实现的。在催化量的Meldrum酸和双官能胺的存在下，各种脂族酮与芳族以及脂族醛均能平稳反应。该协议的亮点是催化剂的易用性，高选择性和官能团耐受性。与碱介导的反应不同，该反应被证明具有高度的E选择性，并且不会因自缩合而产生副产物。

  DOI：

  10.1016/j.tetlet.2018.11.065

文献信息

• Mid-term Results of the Ross Procedure
  作者：Domenico Paparella、Tirone E. David、Susan Armstrong、Joan Ivanov

  DOI：10.1111/j.1540-8191.2001.tb00533.x

  日期：2001.7

  Although the Ross procedure has been performed for over three decades, its role in the management of patients with aortic valve disease is not well established. This study reviews our experience with this operation. From 1990 to 1999, 155 patients underwent the Ross procedure. The mean age of 106 men and 49 women was 35 years. Most patients (85%) had congenital aortic valve disease. The pulmonary autograft was implanted in the subcoronary position in 2 patients, as an aortic root inclusion in 78, and aortic root replacement in 75. The follow-up extended from 9 to 114 months, mean of 45 +/- 28 months, and it was complete. All patients have had Doppler echocardiographic studies. There was only one operative and one late death. The survival was 98% at 7 years. The freedom from 3+ or 4+ aortic insufficiency was 86% at 7 years and the freedom from reoperation on the pulmonary autograft was 95% at 7 years. Dilation of the aortic annulus and/or sinotubular junction was the most common cause of aortic insufficiency. One patient required three reoperations on the biological pulmonary valve. Most patients (96%) have no cardiac symptoms. The Ross procedure has provided excellent functional results in most patients, but progressive aortic insufficiency due to dilation of the aortic annulus and/or sinotubular junction is a potential problem in a number of patients.
• An access to α, β-unsaturated ketones via dual cooperative catalysis
  作者：Lakshmi V.R. Babu Syamala、Tushar M. Khopade、Prakash K. Warghude、Ramakrishna G. Bhat

  DOI：10.1016/j.tetlet.2018.11.065

  日期：2019.1

  A dual cooperative organocatalytic approach for the synthesis of α, β-unsaturated ketones is described. This one pot transformation is realized via a domino Knoevenagel-Michael-retro Michael reaction sequence. Various aliphatic ketones reacted smoothly with aromatic as well as aliphatic aldehydes in presence catalytic amount of Meldrum’s acid and bifunctional amine. The highlights of this protocol

  描述了合成α，β-不饱和酮的双重协同有机催化方法。一锅转换是通过多米诺Knoevenagel-Michael-复古Michael反应序列实现的。在催化量的Meldrum酸和双官能胺的存在下，各种脂族酮与芳族以及脂族醛均能平稳反应。该协议的亮点是催化剂的易用性，高选择性和官能团耐受性。与碱介导的反应不同，该反应被证明具有高度的E选择性，并且不会因自缩合而产生副产物。
• Dimmock, J.R.; Smith, L.M.; Smith, P.J., Canadian Journal of Chemistry, 1980, vol. 58, p. 984 - 991
  作者：Dimmock, J.R.、Smith, L.M.、Smith, P.J.

  DOI：——

  日期：——