endo-cis-Norbornan-2,3-dicarbonsaeure | 2435-37-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: endo-cis-Norbornan-2,3-dicarbonsaeure
• 英文别名: endo-cis-2,3-Dicarboxy-bicyclo<2.2.1>heptan；Norbornan-endo-cis-2,3-dicarbonsaeure；norbornane-2endo,3endo-dicarboxylic acid；Norbornan-2endo,3endo-dicarbonsaeure；(1R,2R,3S,4S)-bicyclo[2.2.1]heptan-2,3-dicarboxylic acid；Norbornan-dicarbonsaeure-(2endo.3endo)；2,3-Norbornanedicarboxylic acid, endo,endo-；(1R,2R,3S,4S)-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid
• CAS: 2435-37-2
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: IVVOCRBADNIWDM-UMRXKNAASA-N

物化性质

• 沸点：
  407.7±28.0 °C(Predicted)
• 密度：
  1.420±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  endo-cis-Norbornan-2,3-dicarbonsaeure 生成 cis-5-norbornene-endo-2,3-dicarboxylic anhydride
  参考文献：
  名称：

  Alder; Stein, Justus Liebigs Annalen der Chemie, 1933, vol. 504, p. 216,232, 252

  摘要：

  DOI：
• 作为产物：
  描述：

  endo-cis-2,3-dimethoxycarbonylnorbornane 在 甲醇 作用下， 生成 endo-cis-Norbornan-2,3-dicarbonsaeure
  参考文献：
  名称：

  Alder; Stein, Justus Liebigs Annalen der Chemie, 1933, vol. 504, p. 216,232, 252

  摘要：

  DOI：

文献信息

• Hydrogen-Free Homogeneous Catalytic Reduction of Olefins in Aqueous Solutions
  作者：Carina Gaviglio、Fabio Doctorovich

  DOI：10.1021/jo800302v

  日期：2008.7.1

  been examined. The steric effects of the substituents on the carbon−carbon multiple bond as well as the regioselectivity and stereoselectivity of the catalyst have been studied. The deuterium kinetic isotope effect on the catalytic reduction of double bonds in olefins has been analyzed, and no significant kinetic isotope effect was found. Among the great advantages of this novel procedure for catalytic

  在本文中，我们报告了一项涉及在水溶液或水-有机溶剂混合物中不饱和底物的均相催化还原的研究。烯烃的还原反应是在催化量的[Fe（CN）5 NH 3 ] 3-和过量的NH 2的存在下进行的OH，在温和的反应条件下，可用于降低碳-碳不饱和度而不影响羰基官能度和芳环。为了探索催化还原的范围，已经研究了多种代表性的不饱和底物。研究了取代基对碳-碳多重键的空间效应以及催化剂的区域选择性和立体选择性。分析了氘的动力学同位素效应对烯烃中双键催化还原的影响，但未发现明显的动力学同位素效应。这种新颖的催化还原方法的主要优点是不需要氢气和高压，该催化剂便宜且易于制备，
• Beta2-Adrenergic Receptor Agonists
  申请人：Moran Edmund J.

  公开号：US20080269344A1

  公开（公告）日：2008-10-30

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多结合化合物，其是β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。
• Novel antibacterial agents
  申请人：Christensen Burton G.

  公开号：US20090111737A1

  公开（公告）日：2009-04-30

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。本发明的多结合化合物包括2-10个配体，这些配体通过连接剂或连接剂共价连接，其中每个单价（即未连接）的配体具有结合细胞壁生物合成和代谢酶、合成细菌细胞壁和/或细菌细胞表面的前体的能力，从而干扰细胞壁的合成和/或代谢。特别是，本发明的多结合化合物包括2-10个配体，这些配体通过连接剂或连接剂共价连接，其中每个配体具有能够结合青霉素结合蛋白、横肽酶酶、横肽酶酶底物、β-内酰胺酶酶、青霉素酶酶、头孢菌素酶酶、横链酶酶或横链酶酶底物的配体结构域；最好选择β-内酰胺类或糖肽类抗菌剂作为配体。
• Mono esters of dicarboxylic acids, their preparation and use
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0373949A1

  公开（公告）日：1990-06-20

  Optically active mono-esters of dicarboxylic acids of the formula III: wherein R¹ is optionally substituted alkyl, menthyl optionally substituted alkenyl, optionally substituted aralkyl; -X- is -0-, -S-, -0-0, -(CH₂)m-, in which m is an integer of from 0 to 4, R² is hydrogen, methyl, or ethyl, and R³ is hydrogen, methyl, benzyloxycarbonyl or formyl; -Y- is -(CH₂)n-, in which n is an integer of from 0 to 3, R² is the same as defined above, and R⁴ is hydrogen, methyl, or ethyl; and Z is hydrogen, lower alkyl, or phenyl; provided that m and n are not both zero, are useful as intermediates for preparing optically active natural products or medicines. The invention includes an asymmetric synthesis process for the preparation thereof characterised by the reaction of an acid anhydride with an (R)- or (S)-arylacetic acid derivative.

  式 III 的二羧酸光学活性单酯： 其中 R¹ 是任选取代的烷基、任选取代的烯基、任选取代的芳基；-X- 是-0-、-S-、-0-0、-(CH₂)m-、 其中 m 是 0 到 4 的整数，R² 是氢、甲基或乙基，R³ 是氢、甲基、苄氧羰基或甲酰基； -Y-是-(CH₂)n-、 其中，n 为 0 至 3 的整数，R² 与上文所定义的相同，R⁴ 为氢、甲基或乙基；Z 为氢、低级烷基或苯基；只要 m 和 n 均不为零，则可用作制备光学活性天然产物或药物的中间体。本发明包括制备其的不对称合成工艺，其特征在于酸酐与 (R)- 或 (S)- 芳基乙酸衍生物的反应。
• PROPYLENE-BASED RESIN COMPOSITION AND INJECTION-MOLDED OBJECT THEREOF
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3467022A1

  公开（公告）日：2019-04-10

  Provided is a propylene-based resin composition comprising the following component (A), the following component (B) and a component (C), wherein based on the total weight of the component (A) and the component (B), which is taken as 100 parts by weight, the content of the component (A) is 50 to 89 parts by weight, the content of the component (B) is 11 to 50 parts by weight, and the content of the component (C) is 0.05 to 1 part by weight: component (A): a propylene-based polymer component (B): a filler component (C): a bis(3,4-dialkylbenzylidene)sorbitol represented by the following formula (1) wherein R1 and R2 each independently of each other represent an alkyl group having 1 to 4 carbon atoms. It is possible to produce a molded article which has high rigidity and in which the linear expansion coefficients in the MD and the TD are small from the composition.

  本发明提供了一种丙烯基树脂组合物，该组合物由以下组分（A）、以下组分（B）和组分（C）组成，其中基于组分（A）和组分（B）的总重量（按重量计为 100 份），组分（A）的含量按重量计为 50 至 89 份，组分（B）的含量按重量计为 11 至 50 份，组分（C）的含量按重量计为 0.05 至 1 份： 组分（A）：丙烯基聚合物 组分（B）：填料 组分（C）：由下式（1）表示的双(3,4-二烷基亚苄基)山梨醇 其中 R1 和 R2 各自独立地代表具有 1 至 4 个碳原子的烷基。 通过这种组合物，可以生产出具有高刚性且 MD 和 TD 线性膨胀系数较小的模塑制品。