2-丁基-3-甲基-6-丙-2-基苯酚 | 74927-04-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 2-丁基-3-甲基-6-丙-2-基苯酚
• 中文别名: N-(3-苯基丙酰)-L-酪氨酸
• 英文名称: 2-Butyl-6-isopropyl-3-methyl-phenol
• 英文别名: Phenol, 2-butyl-6-isopropyl-3-methyl-；2-butyl-3-methyl-6-propan-2-ylphenol
• CAS: 74927-04-1
• 化学式: C₁₄H₂₂O
• 分子量: 206.328
• InChiKey: CXUXTUZJLWFBQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为产物：
  描述：

  百里酚 在 W₂ Raney nickel N-氯代丁二酰亚胺 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 28.5h， 生成 2-丁基-3-甲基-6-丙-2-基苯酚
  参考文献：
  名称：

  Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents

  摘要：

  Following our discovery of the intravenous (iv) anesthetic activity of 2,6-diethylphenol in mice, a series of alkylphenols was examined in this species and the most active analogues were further evaluated in rabbits. The synthesis of compounds which were not commercially available was accomplished by adaptations of standard ortho-alkylation procedures for phenols. Structure-activity relationships were found to be complex, but, in general, potency and kinetics appeared to be a function of both the lipophilic character and the degree of steric hindrance exerted by ortho substituents. The most interesting compounds were found in the 2,6-dialkyl series, and the greatest potency was associated with 2,6-di-sec-alkyl substitution. In particular, 2,6-diisopropylphenol (ICI 35 868) emerged as a candidate for further development and has subsequently been shown to be an effective iv anesthetic agent in man.

  DOI：

  10.1021/jm00186a013

文献信息

• Sen; Parmar, Journal of the Indian Chemical Society, 1953, vol. 30, p. 801
  作者：Sen、Parmar

  DOI：——

  日期：——
• PROCESS FOR PREPARING 3,3',6,6'-TETRAALKYL-2,2'-BIPHENOLS AND 3,3',6,6'-TETRAALKYL-5,5'-DIHALO-2,2'-BIPHENOLS
  申请人：Invista Technologies S.à.r.l.

  公开号：EP1448503A1

  公开（公告）日：2004-08-25
• PROCESS FOR PREPARING 3,3',5,5',6,6'-HEXAALKYL-2,2'-BIPHENOLS, 3,3',4,4',5,5'-HEXAALKYL-2,2'-BIPHENOLS AND 3,3',4,4',5,5',6,6'-OCTAALKYL-2,2'-BIPHENOLS
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1467958A1

  公开（公告）日：2004-10-20
• PROCESS AND APPARATUS FOR PRODUCING ALIPHATIC POLYESTER
  申请人：Hayashi Naoki

  公开号：US20120309929A1

  公开（公告）日：2012-12-06

  A process for producing an aliphatic polyester includes the steps of: heating a cyclic ester at a melting point or higher to transform the cyclic ester into molten state and convert a moisture contained in the cyclic ester into free carboxylic acid; measuring an amount of the free carboxylic acid in the molten cyclic ester; feeding a proton-source compound in an amount determined based on the measured amount of the free carboxylic acid into the molten cyclic ester; and subjecting the cyclic ester to ring-opening polymerization. The process provides an aliphatic polyester with a desired molecular weight which can be set easily and accurately. An apparatus for the process is also provided.
• [EN] PROCESS FOR PREPARING 3,3',6,6'-TETRAALKYL-2,2'-BIPHENOLS AND 3,3',6,6'-TETRAALKYL-5,5'-DIHALO-2,2'-BIPHENOLS<br/>[FR] PROCEDE DE PREPARATION DE 3,3',6,6'-TETRAALKYL-2,2'-BIPHENOLS ET DE 3,3',6,6'-TETRAALKYL-5,5'-DIHALO-2,2'-BIPHENOLS
  申请人：DU PONT

  公开号：WO2003045884A1

  公开（公告）日：2003-06-05

  A process for making a compound of the formula (I).