2-(4-methylenecyclohexylidene)ethanol | 402857-94-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-methylenecyclohexylidene)ethanol
• 英文别名: 2-(4-Methylidenecyclohexylidene)ethanol；2-(4-methylidenecyclohexylidene)ethanol
• CAS: 402857-94-7
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: KEURDELRMKVTLA-UHFFFAOYSA-N

物化性质

• 沸点：
  238.9±9.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-methylenecyclohexylidene)ethanol 在 [hCH=RuCl₂(PCy₃)2] mercury(II) diacetate 、 碳酸氢钠 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 8-methylenespiro<4,5>dec-3-en-2-one
  参考文献：
  名称：

  A Ring Closing Metathesis Based Approach for the Spiroannulation of Cyclopentanes and Cyclohexanes. Formal Synthesis of (±)-Acorones

  摘要：

  开发了一种高效的环关闭 метатезис（RCM）反应方法，用于环戊烷和环己烷的螺环化，并在正式合成螺二萜酸（spirosesquiterpenes acorones）中展示了其应用价值。

  DOI：

  10.1055/s-2001-18743
• 作为产物：
  描述：

  1,4-环己二酮 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 乙醚 、 苯 为溶剂， 反应 5.17h， 生成 2-(4-methylenecyclohexylidene)ethanol
  参考文献：
  名称：

  A Ring Closing Metathesis Based Approach for the Spiroannulation of Cyclopentanes and Cyclohexanes. Formal Synthesis of (±)-Acorones

  摘要：

  开发了一种高效的环关闭 метатезис（RCM）反应方法，用于环戊烷和环己烷的螺环化，并在正式合成螺二萜酸（spirosesquiterpenes acorones）中展示了其应用价值。

  DOI：

  10.1055/s-2001-18743

文献信息

• Srikrishna; Rao, M. Srinivasa, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 9, p. 1423 - 1429
  作者：Srikrishna、Rao, M. Srinivasa

  DOI：——

  日期：——
• 3-DESOXY-2-METHYLENE-19-NOR-VITAMIN D ANALOGS AND THEIR USES
  申请人：Wisconsin Alumni Research Foundation

  公开号：EP2721004B1

  公开（公告）日：2017-07-26
• 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses
  申请人：DeLuca Hector F.

  公开号：US20120157418A1

  公开（公告）日：2012-06-21

  This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin D 3 and (20R)-25-hydroxy-2-methylene-19-nor-vitamin D 3 , as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. Although these compounds have relatively low calcemic activities they may also be useful in the treatment of bone diseases due to their ability to act as prodrugs in vivo.
• [EN] 1-DESOXY-2-METHYLENE-19-NOR-VITAMIN D ANALOGS AND THEIR USES<br/>[FR] ANALOGUES DE 1-DÉSOXY-2-MÉTHYLÈNE-19-NOR-VITAMINE D ET LEURS UTILISATIONS
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2011041590A2

  公开（公告）日：2011-04-07

  This invention discloses l-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25 -hydroxy- l-desoxy-2-methylene-19-nor- vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
• A Ring Closing Metathesis Based Approach for the Spiroannulation of Cyclopentanes and Cyclohexanes. Formal Synthesis of (±)-Acorones
  作者：A. Srikrishna、M. Srinivasa Rao、Santosh J. Gharpure、N. Chandrasekhar Babu

  DOI：10.1055/s-2001-18743

  日期：——

  An efficient ring closing methathesis (RCM) reaction based approach was developed for the spiroannulation of cyclopentanes and cyclohexanes and its utility demonstrated in the formal synthesis of the spirosesquiterpenes acorones.

  开发了一种高效的环关闭 метатезис（RCM）反应方法，用于环戊烷和环己烷的螺环化，并在正式合成螺二萜酸（spirosesquiterpenes acorones）中展示了其应用价值。