3-(3,4-dimethoxyphenyl)-N-pyridin-2-ylprop-2-enamide | 544457-71-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(3,4-dimethoxyphenyl)-N-pyridin-2-ylprop-2-enamide
• CAS: 544457-71-8
• 化学式: C₁₆H₁₆N₂O₃
• mdl: MFCD00476918
• 分子量: 284.315
• InChiKey: UCVMKQIIEBIBRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 3,4-二甲氧基肉桂酸 在 silica gel 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以86%的产率得到3-(3,4-dimethoxyphenyl)-N-pyridin-2-ylprop-2-enamide
  参考文献：
  名称：

  Silica Gel-Mediated Amide Bond Formation: An Environmentally Benign Method for Liquid-Phase Synthesis and Cytotoxic Activities of Amides

  摘要：

  DOI：

  10.1021/cc900135f

文献信息

• Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents
  作者：Georges Koumba Yoya、Florence Bedos-Belval、Patricia Constant、Hubert Duran、Mamadou Daffé、Michel Baltas

  DOI：10.1016/j.bmcl.2008.11.082

  日期：2009.1

  In an effort to develop potent new antituberculous drugs effective against Mycobacterium tuberculosis, we have prepared series of cinnamic derivatives (thioesters and amides) with 4-hydroxy and 4-alkoxy groups and investigated the in vitro activities of these compounds. Among them some displayed a good in vitro antibacterial activity, such as (E)-N-(2-acetamidoethyl)-3-4-[(E)-3,7-dimethylocta-2,6-dienyloxy]phenyl} acrylamide 4b that showed a minimum inhibitory concentration of 0.1 mu g/mL (0.26 mu M) against M. tuberculosis H37Rv. (C) 2008 Elsevier Ltd. All rights reserved.
• Silica Gel-Mediated Amide Bond Formation: An Environmentally Benign Method for Liquid-Phase Synthesis and Cytotoxic Activities of Amides
  作者：Xiao-Dong Yang、Xiang-Hui Zeng、Yuan-Hong Zhao、Xue-Quan Wang、Zhi-Qiang Pan、Liang Li、Hong-Bin Zhang

  DOI：10.1021/cc900135f

  日期：2010.5.10