allose (α-furanose) | 36468-79-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: allose (α-furanose)
• 英文别名: alpha-D-allofuranose；(2S,3R,4S,5R)-5-[(1R)-1,2-dihydroxyethyl]oxolane-2,3,4-triol
• CAS: 36468-79-8
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: AVVWPBAENSWJCB-RXRWUWDJSA-N

物化性质

• 沸点：
  476.9±45.0 °C(Predicted)
• 密度：
  1.777±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  allose (α-furanose) 、 丙酮 在 2,2-二甲氧基丙烷 作用下， 反应 3.0h， 生成 双丙酮葡萄糖
  参考文献：
  名称：

  磺酸功能化有序介孔二氧化硅及其在1,2-单丙酮-D-葡萄糖形成中的高效选择性多相催化剂中的应用

  摘要：

  通过合成后接枝方法制备了一系列磺酸功能化的有序介孔二氧化硅（OMS），命名为RSO 3 H-OMS（R =烷基或芳基; OMS = MCM-41，IITM-56或SBA-15） 。这些催化剂通常显示出强酸性位，因此在D-葡萄糖丙酮化反应中产生双丙酮D-葡萄糖作为主要产物。另一方面，功能化催化剂也可以进行调节，以产生大量弱至中度的酸性位点，这些位点又会导致1,2-单丙酮-D的形成。葡萄糖，迄今为止尚未报道。这些功能化的材料还显示出希望，因为它们是耐水催化剂，并且表现出不同的酸性强度，这为所需产品提供了更大的灵活性。另外，具有高表面积的均匀中孔允许较大分子进入活性位点，因此催化剂在产率和可重复使用性方面提供较大的柔韧性。我们在这里报告，对于第一次，RSO 3 H-SBA-15，具有相当大的量弱至中度酸性位点的，作为用于目标分子，1,2- monoacetone-形成一个坚固的非均相催化剂d -葡萄糖。

  DOI：

  10.1002/cctc.201801462

文献信息

• CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US20150238597A1

  公开（公告）日：2015-08-27

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及合成和生物评价一种新型基于碳水化合物的疫苗的领域。这种新疫苗由多模块结构组成，可以将疫苗应用于各种病原体。该方法允许制备针对所有表达免疫原碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质结合，所以结合疫苗尤其耐热稳定。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• Monosaccharide derivatives
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1864992A2

  公开（公告）日：2007-12-12

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinids and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

  本发明涉及单糖衍生物作为抗炎症剂。本文披露的化合物可用于抑制和预防炎症及相关病理，包括支气管哮喘、类风湿关节炎、Ⅰ型糖尿病、多发性硬化、移植排斥、牛皮癣、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒症和过敏性鼻炎等炎症性和自身免疫性疾病。还提供了含有本文披露的化合物的药理组合物和治疗支气管哮喘、慢性阻塞性肺病、类风湿关节炎、多发性硬化、Ⅰ型糖尿病、牛皮癣、移植排斥、炎症性肠病、溃疡性结肠炎、痤疮、动脉粥样硬化、癌症、瘙痒症、过敏性鼻炎和其他炎症和/或自身免疫性疾病的方法。
• Carbohydrate-glycolipid conjugate vaccines
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US10588962B2

  公开（公告）日：2020-03-17

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及一类基于碳水化合物的新型疫苗的合成和生物评估领域。这种新型疫苗由多模块结构组成，可将疫苗应用于各种病原体。这种方法可以制备出针对所有表达免疫原性碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质共轭，共轭疫苗的热稳定性特别好。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• Novel class of saccharide-based organogelators: glucofuranose derivatives as one of the smallest and highly efficient gelators
  作者：Roman Luboradzki、Zbigniew Pakulski

  DOI：10.1016/j.tet.2004.03.074

  日期：2004.5

  Gluco- and allofuranose derivatives, having unprotected three OH groups, were investigated as potential gelators, showing high gelating ability for a variety of organic solvents and result in new consistent class of organogelators. The minimum gelator concentration reaches 0.03%. which is one of the lowest concentrations achieved so far. The correlation between the saccharide crystal structure and its gelating ability was also examined. The SEM pictures of xerogeles obtained from concentrated and diluted gels (1.0-0.03%) show significant differences in mum-scale structure. (C) 2004 Elsevier Ltd. All rights reserved.
• Enzyme Assays on a Droplet Actuator
  申请人：Advanced Liquid Logic, Inc.

  公开号：US20170159105A1

  公开（公告）日：2017-06-08

  The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.