N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester | 329212-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[(3-nitrophenyl)methylideneamino]carbamate
• CAS: 329212-43-3
• 化学式: C₁₂H₁₅N₃O₄
• 分子量: 265.269
• InChiKey: ZHELXCPMQSVBSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester 在 N-氯代丁二酰亚胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.2h， 生成 5-(3-nitrophenyl)-1,3,4-oxadiazol-2-ol
  参考文献：
  名称：

  Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl-methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

  摘要：

  The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N'-(chloro-aryl-methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.128
• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 间硝基苯甲醛 在 4-甲基苯磺酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.12h， 以93%的产率得到N-[(3-nitrophenyl)methylideneamino]carbamic acid tert-butyl ester
  参考文献：
  名称：

  使用简化的计算机视觉控制的液液萃取系统连续流合成氨基甲酸az

  摘要：

  计算机视觉控制的液-液萃取系统用于一系列氨基甲酸酯的连续流合成。该系统使用开源软件组件（Python，OpenCV），并且在硬件方面比我们先前描述的更为简单，并且可能更经济。

  DOI：

  10.1016/j.tetlet.2016.10.018

文献信息

• Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl-methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition
  作者：Kamalesh Debnath、Sudipta Pathak、Animesh Pramanik

  DOI：10.1016/j.tetlet.2012.11.128

  日期：2013.2

  The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N'-(chloro-aryl-methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity. (C) 2012 Elsevier Ltd. All rights reserved.
• The continuous-flow synthesis of carbazate hydrazones using a simplified computer-vision controlled liquid–liquid extraction system
  作者：Matthew O’Brien、Dennis A. Cooper、Panashe Mhembere

  DOI：10.1016/j.tetlet.2016.10.018

  日期：2016.11

  A computer-vision controlled liquid–liquid extraction system was used in the continuous-flow synthesis of a series of carbazate hydrazones. The system uses open-source software components (Python, OpenCV) and is simpler and potentially more economical, in terms of hardware, than one we have described previously.

  计算机视觉控制的液-液萃取系统用于一系列氨基甲酸酯的连续流合成。该系统使用开源软件组件（Python，OpenCV），并且在硬件方面比我们先前描述的更为简单，并且可能更经济。