4-(1,3-di(quinolin-2-yl)propan-2-yl)benzonitrile | 1446451-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(1,3-di(quinolin-2-yl)propan-2-yl)benzonitrile
• 英文别名: 4-[1,3-Di(quinolin-2-yl)propan-2-yl]benzonitrile；4-[1,3-di(quinolin-2-yl)propan-2-yl]benzonitrile
• CAS: 1446451-56-4
• 化学式: C₂₈H₂₁N₃
• 分子量: 399.495
• InChiKey: FGPOHHKFCUOBHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基喹啉 、 4-氰基苯甲醛 在 对甲苯磺酸 作用下， 以 对二甲苯 为溶剂， 反应 24.0h， 以85%的产率得到4-(1,3-di(quinolin-2-yl)propan-2-yl)benzonitrile
  参考文献：
  名称：

  Brønsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)–H functionalization

  摘要：

  A novel protocol for Bronsted acid catalyzed reaction of 2-methyl azaarenes and aromatic aldehyde to give 1,3-di(2-quinolyl)propane derivatives through tandem C(sp(3))-H bond functionalization has been developed. This approach provides a new access to a variety of 1,3-di(2-quinolyl)propane derivatives, which are potentially of great importance in pharmaceuticals and ligand fields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.135

文献信息

• Brønsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)–H functionalization
  作者：Jia-jia Jin、Dong-chao Wang、Hong-ying Niu、Shan Wu、Gui-rong Qu、Zhong-bo Zhang、Hai-ming Guo

  DOI：10.1016/j.tet.2013.05.135

  日期：2013.8

  A novel protocol for Bronsted acid catalyzed reaction of 2-methyl azaarenes and aromatic aldehyde to give 1,3-di(2-quinolyl)propane derivatives through tandem C(sp(3))-H bond functionalization has been developed. This approach provides a new access to a variety of 1,3-di(2-quinolyl)propane derivatives, which are potentially of great importance in pharmaceuticals and ligand fields. (C) 2013 Elsevier Ltd. All rights reserved.