1-(4-(cyclooctylamino)phenyl)ethanone | 1186522-02-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(cyclooctylamino)phenyl)ethanone
• 英文别名: 1-[4-(Cyclooctylamino)phenyl]ethanone；1-[4-(cyclooctylamino)phenyl]ethanone
• CAS: 1186522-02-0
• 化学式: C₁₆H₂₃NO
• mdl: MFCD26968922
• 分子量: 245.365
• InChiKey: OKLFAUVAEGBSHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.562
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环辛烷 、 对硝基苯乙酮 在 air 、 过氧化二异丙苯 作用下， 反应 16.0h， 以47%的产率得到1-(4-(cyclooctylamino)phenyl)ethanone
  参考文献：
  名称：

  过氧化氢介导的环戊烷与硝基芳烃的胺化反应

  摘要：

  Abstractmagnified imageA direct amination of simple cycloalkanes with nitroarenes mediated by peroxides has been discovered. Various secondary arylamines were obtained efficiently from cycloalkanes. The reaction tolerates a wide range of functionalities as well as aqueous conditions. No metal was required for this novel amination reaction.

  DOI：

  10.1002/adsc.200800689

文献信息

• An Unusual Peroxide-Mediated Amination of Cycloalkanes with Nitroarenes
  作者：Guojun Deng、Wenwen Chen、Chao-Jun Li

  DOI：10.1002/adsc.200800689

  日期：2009.2

  Abstractmagnified imageA direct amination of simple cycloalkanes with nitroarenes mediated by peroxides has been discovered. Various secondary arylamines were obtained efficiently from cycloalkanes. The reaction tolerates a wide range of functionalities as well as aqueous conditions. No metal was required for this novel amination reaction.