D-Ribonate | 21370-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Ribonate
• 英文别名: ribonate；(2R,3R,4R)-2,3,4,5-tetrahydroxypentanoate
• CAS: 21370-07-0
• 化学式: C₅H₉O₆
• 分子量: 165.123
• InChiKey: QXKAIJAYHKCRRA-BXXZVTAOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  D-Ribonate 在 乙二胺四乙酸 、 Proteus mirabilis 、 四环素 、 anthraquinone-2,6-disulfonate 、 二甲基亚砜 作用下， 以 水 为溶剂， 以71%的产率得到D-erythro-Pent-2-ulosonat
  参考文献：
  名称：

  Schinschel, Carsten; Simon, Helmut, Angewandte Chemie, 1993, vol. 105, # 8, p. 1221 - 1223

  摘要：

  DOI：
• 作为产物：
  描述：

  氰化钾 、 (2R,3R)-2,3,4-三羟基丁醛 在 水 作用下， 生成 D-Arabinonate 、 D-Ribonate
  参考文献：
  名称：

  Cyanohydrin synthesis: studies with carbon-13-labeled cyanide

  摘要：

  DOI：

  10.1021/jo01304a038
• 作为试剂：
  描述：

  Sodium ribonate 、 、 D-Ribonate 、 (2R,3R)-2,3,4-三羟基丁醛 、 Erythritol 、 硼氢化钠 在 H+ 、 D-Ribonate 作用下， 以 水 为溶剂， 生成 D-核糖酸
  参考文献：
  名称：

  Methods for the electrolytic production of erythrose or erythritol

  摘要：

  本文提供了生产赤糖醛和/或赤藓醇的方法。首选，该方法包括通过电解脱羧反应将核糖酸或阿拉伯糖酸反应物产生赤糖醛。可选地，反应物可以从适当的己糖类糖中获得，例如阿洛糖、阿尔特糖、葡萄糖、果糖或甘露糖。赤糖醛产物可以氢化以产生赤藓醇。

  公开号：

  US07955489B2

文献信息

• METHODS FOR THE ELECTROLYTIC PRODUCTION OF ERYTHRITOL
  申请人：Stapley Jonathan A.

  公开号：US20110272291A1

  公开（公告）日：2011-11-10

  Methods for the production of erythrose and/or erythritol are provided herein. Preferably, the method of producing erythritol includes the step of electrolytic decarboxylation of a ribonic acid or arabinonic acid reactant to produce erythrose and the step of electrolytic reduction or erythrose to produce erythritol. Optionally, the reactant can be obtained from a suitable hexose sugar, such as allose, altrose, glucose, fructose or mannose.

  本文提供了生产赤藓糖和/或赤藓醇的方法。最好的生产赤藓醇的方法包括以下步骤：通过电解脱羧化核糖酸或阿拉伯糖酸反应物来产生赤藓糖，以及通过电解还原赤藓糖来产生赤藓醇。可选地，反应物可以从适当的己糖糖中获得，例如阿洛糖、阿尔特糖、葡萄糖、果糖或甘露糖。
• Methods for the electrolytic production of erythritol
  申请人：Stapley Jonathan A.

  公开号：US09133554B2

  公开（公告）日：2015-09-15

  Methods for the production of erythrose and/or erythritol are provided herein. Preferably, the method of producing erythritol includes the step of electrolytic decarboxylation of a ribonic acid or arabinonic acid reactant to produce erythrose and the step of electrolytic reduction or erythrose to produce erythritol. Optionally, the reactant can be obtained from a suitable hexose sugar, such as allose, altrose, glucose, fructose or mannose.

  本文提供了生产赤糖醇和/或赤糖的方法。最好的生产赤糖醇的方法包括通过电解脱羧反应得到赤霉糖酸或阿拉伯糖酸产生赤糖，然后通过电解还原反应将赤糖转化为赤糖醇。可选地，反应物可以从适当的六碳糖（如阿洛糖、阿尔曲糖、葡萄糖、果糖或甘露糖）中获得。
• Pentose metabolism in Candida
  作者：B.M. Scher、B.L. Horecker

  DOI：10.1016/0003-9861(66)90020-8

  日期：——
• Schiwara H.W.; Domschke W.; Domagk G.F., Hoppe Seylers Z Physiol Chem, 1968, 0018-4888, 1575-81
  作者：Schiwara H.W.、Domschke W.、Domagk G.F.

  DOI：——

  日期：——
• Identification of the Missing Links in Prokaryotic Pentose Oxidation Pathways
  作者：Stan J.J. Brouns、Jasper Walther、Ambrosius P.L. Snijders、Harmen J.G. van de Werken、Hanneke L.D.M. Willemen、Petra Worm、Marjon G.J. de Vos、Anders Andersson、Magnus Lundgren、Hortense F.M. Mazon、Robert H.H. van den Heuvel、Peter Nilsson、Laurent Salmon、Willem M. de Vos、Phillip C. Wright、Rolf Bernander、John van der Oost

  DOI：10.1074/jbc.m605549200

  日期：2006.9

  The pentose metabolism of Archaea is largely unknown. Here, we have employed an integrated genomics approach including DNA microarray and proteomics analyses to elucidate the catabolic pathway for D-arabinose in Sulfolobus solfataricus. During growth on this sugar, a small set of genes appeared to be differentially expressed compared with growth on D-glucose. These genes were heterologously overexpressed in Escherichia coli, and the recombinant proteins were purified and biochemically studied. This showed that D-arabinose is oxidized to 2-oxoglutarate by the consecutive action of a number of previously uncharacterized enzymes, including a D-arabinose dehydrogenase, a D-arabinonate dehydratase, a novel 2-keto-3-deoxy-D-arabinonate dehydratase, and a 2,5-dioxopentanoate dehydrogenase. Promoter analysis of these genes revealed a palindromic sequence upstream of the TATA box, which is likely to be involved in their concerted transcriptional control. Integration of the obtained biochemical data with genomic context analysis strongly suggests the occurrence of pentose oxidation pathways in both Archaea and Bacteria, and predicts the involvement of additional enzyme components. Moreover, it revealed striking genetic similarities between the catabolic pathways for pentoses, hexaric acids, and hydroxyproline degradation, which support the theory of metabolic pathway genesis by enzyme recruitment.