4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide | 1300031-57-5
中文名称
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中文别名
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英文名称
4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide
英文别名
4-Chloro-7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinoline-3-carboxamide；4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxyquinoline-3-carboxamide
CAS
1300031-57-5
化学式
C16H14ClN3O3
mdl
——
分子量
331.758
InChiKey
FLBUVOLGZFTRNG-UHFFFAOYSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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沸点：478.9±45.0 °C(Predicted)
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密度：1.352±0.06 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：2.5
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重原子数：23
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可旋转键数：3
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环数：3.0
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sp3杂化的碳原子比例：0.19
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拓扑面积：91.2
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氢给体数：1
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氢受体数：5
安全信息
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危险性防范说明：P261,P280,P301+P312,P302+P352,P305+P351+P338
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危险性描述：H302,H315,H319,H335
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— 7-(3,5-dimethyl-4-isoxazolyl)-4-hydroxy-6-(methyloxy)-3-quinolinecarboxylic acid 1300737-70-5 C16H14N2O5 314.298 —— ethyl 7-(3,5-dimethyl-4-isoxazolyl)-4-hydroxy-6-(methyloxy)-3-quinolinecarboxylate 1300737-71-6 C18H18N2O5 342.351 —— 3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole 1300031-62-2 C12H12N2O4 248.238 —— diethyl({[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amino}methylidene)propanedioate 1300031-60-0 C20H24N2O6 388.42 —— 3-(3,5-dimethylisoxazol-4-yl)-4-methoxyaniline 1300031-61-1 C12H14N2O2 218.255 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 7-(3,5-dimethyl-4-isoxazolyl)-4-{[(5-methyl-3-isoxazolyl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide 1300737-75-0 C21H21N5O4 407.429 —— 4-(Cyclohexylamino)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxyquinoline-3-carboxamide 1372132-46-1 C22H26N4O3 394.473 —— 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-quinolinecarboxamide 1403491-37-1 C22H26N4O4 410.473 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-4-(2-fluoroanilino)-6-methoxyquinoline-3-carboxamide 1372132-40-5 C22H19FN4O3 406.416 —— 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-4-((pyridin-2-ylmethyl)amino)quinoline-3-carboxamide 1300737-80-7 C22H21N5O3 403.44 —— 4-(2-Tert-butylanilino)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxyquinoline-3-carboxamide 1373354-27-8 C26H28N4O3 444.533 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-(quinolin-8-ylamino)quinoline-3-carboxamide 1372132-45-0 C25H21N5O3 439.473 —— 7-(3,5-dimethyl-4-isoxazolyl)-4-{[(5-methyl-2-furanyl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide 1300737-79-4 C22H22N4O4 406.441 —— 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-phenylethyl]amino}-3-quinolinecarboxamide 1403491-34-8 C24H24N4O3 416.48 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-[2-(2-morpholin-4-ylethyl)anilino]quinoline-3-carboxamide 1373354-29-0 C28H31N5O4 501.585 7-(3,5-二甲基异恶唑-4-基)-6-甲氧基-4-(((R)-1-(吡啶-2-基)乙基)氨基 7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-[[(1R)-1-(pyridin-2-yl)ethyl]amino]quinolone-3-carboxamide 1300737-69-2 C23H23N5O3 417.467 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-[2-(piperidine-1-carbonyl)anilino]quinoline-3-carboxamide 1373354-33-6 C28H29N5O4 499.569 —— 7-(3,5-dimethyl-4-isoxazolyl)-4-{[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]amino}-6-(methyloxy)-3-quinolinecarboxamide 1300737-73-8 C22H23N5O3S 437.522 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-(2-morpholin-4-ylanilino)quinoline-3-carboxamide 1373354-32-5 C26H27N5O4 473.531 —— 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[1-(1-methyl-1H-pyrazol-4-yl)ethyl]amino}-3-quinolinecarboxamide 1300737-72-7 C22H24N6O3 420.471 —— 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-[2-(pyridine-2-carbonyl)anilino]quinoline-3-carboxamide 1373354-30-3 C28H23N5O4 493.522 —— 2-chloro-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinoline 1403491-39-3 C22H23ClN4O3 426.903 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(3-pyridinylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-49-2 C22H19N5O3 401.425 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1403491-38-2 C22H24N4O4 408.457 —— 2-chloro-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinoline 1403491-35-9 C24H21ClN4O2 432.909 —— 7-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(2-fluorophenyl)-8-methoxy-3H-imidazo[4,5-c]quinolin-2-one 1300735-18-5 C22H17FN4O3 404.4 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(2-pyrimidinylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-47-0 C21H18N6O3 402.412 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(2-pyrazinylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-48-1 C21H18N6O3 402.412 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(2-thienylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-53-8 C21H18N4O3S 406.465 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-73-2 C24H22N4O3 414.464 —— 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(pyridin-2-ylmethyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-15-2 C22H19N5O3 401.425 —— 7-(3,5-dimethyl-4-isoxazolyl)-1-[(5-methyl-3-isoxazolyl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-52-7 C21H19N5O4 405.413 —— 7-(3,5-dimethyl-4-isoxazolyl)-1-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-50-5 C22H21N5O3S 435.506 —— 7-(3,5-dimethyl-4-isoxazolyl)-1-[(5-methyl-2-furanyl)methyl]-8-(methyloxy)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-55-0 C22H20N4O4 404.425 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[1-(1-methyl-1H-pyrazol-4-yl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one 1300735-42-5 C22H22N6O3 418.455 —— 2-{[7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-2-yl]amino}ethanol 1403491-49-5 C24H29N5O4 451.525 —— 2-({7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinolin-2-yl}amino)ethanol 1403491-47-3 C26H27N5O3 457.532 7-(3,5-二甲基异噁唑-4-基)-8-甲氧基-1-((R)-1-(吡啶-2-基)乙基)-1H-咪唑并[4,5-c]喹啉-2(3H)-酮 I-BET151 1300031-49-5 C23H21N5O3 415.451 —— 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-2-(4-morpholinyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinoline 1403491-65-5 C26H31