Sericoside | 55306-04-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Sericoside
• 英文别名: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1S,4aR,6aS,6bR,9S,10R,11R,12aR)-1,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• CAS: 55306-04-2；62319-70-4
• 化学式: C₃₆H₅₈O₁₁
• 分子量: 666.85
• InChiKey: CMZFNIMQBCBHEX-TXYDQLOPSA-N

物化性质

• 沸点：
  775.0±60.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3 (20 ºC 760 Torr)
• LogP：
  2.356 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  47
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  197
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20150290233A1

  公开（公告）日：2015-10-15

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• SYNAPTOJANIN-2 INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20170042857A1

  公开（公告）日：2017-02-16

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.