2α,3β,23,24-tetrahydroxyolean-12-en-28-oic acid | 116787-93-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2α,3β,23,24-tetrahydroxyolean-12-en-28-oic acid
• 英文别名: belleric acid；(4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 116787-93-0
• 化学式: C₃₀H₄₈O₆
• 分子量: 504.708
• InChiKey: IHSNIFFMIWMPRL-DCGQWPFASA-N

物化性质

• 熔点：
  300 °C(Solv: methanol (67-56-1))
• 沸点：
  642.7±55.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2α,3β,23,24-tetrahydroxyolean-12-en-28-oic acid 、 重氮甲烷 生成 2α,3β,23,24-tetrahydroxyolean-12-en-28-oic acid methyl ester
  参考文献：
  名称：

  NANDY, ASHOKE K.;PODDER, GURUDAS;SAHU, NIRANJAN P.;MAHATO, SHASHI B., PHYTOCHEMISTRY, 28,(1989) N0, C. 2769-2772

  摘要：

  DOI：

文献信息

• ACCELERATOR FOR INITIAL INSULIN SECRETION
  申请人：Use-Techno Corporation

  公开号：EP1674089A1

  公开（公告）日：2006-06-28

  The present invention provides an early insulin secretion stimulator consisting of a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]

  本发明提供了一种早期胰岛素分泌刺激剂，由以下通式（1）代表的三萜和/或以下通式（2）代表的三萜组成。 [其中 R1 代表 COOH 等，R11 和 R12 代表 CH2OH 等，X1 代表氢或 OH，X11、X12、X21 和 X22 代表 OH 等。］
• Polynucleotide binding complexes comprising sterols and saponin
  申请人：Nordic Vaccine Technology A/S

  公开号：EP2011517A1

  公开（公告）日：2009-01-07

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

  本发明涉及由甾醇和皂甙组成的复合物。这些复合物能够结合包括多核苷酸在内的遗传决定因子。复合物可进一步包含亲脂分子，可选择包含接触基团和/或靶向配体的亲脂分子和/或糖分子。复合物可进一步包括免疫原决定簇和/或抗原决定簇和/或药物和/或诊断化合物。在更进一步的实施方案中，复合物可被包括生物可降解微球在内的封装剂封装。本发明还涉及通过治疗和/或手术对个体进行治疗的药物组合物和方法、美容治疗方法以及对人体或动物体进行诊断的方法。
• Botanical extracts and compounds from Castanea plants and methods of use
  申请人：Emory University

  公开号：US10195241B2

  公开（公告）日：2019-02-05

  This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.

  本公开涉及从栗树植物中提取的提取物以及包含其中所含化合物的组合物。在某些实施方案中，提取物来自蓖麻植物的叶子。在某些实施方案中，本公开涉及治疗或预防细菌感染、痤疮及其他相关用途的方法。
• IMPROVED HERBAL COMPOSITION HAVING ANTIALLERGIC PROPERTIES AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：——

  公开号：US20030194452A1

  公开（公告）日：2003-10-16

  The present invention relating to a herbal antiallergic composition which comprises a synergistic mixture of extracts from the fruits of Terminalia chebula , bark of Albizia lebbeck, Terminalia bellerica and Emblica officinalis . The present invention also contains the fruits of Piper longum. Piper nigrum and of rhizomes of Zingiber officinale and thoroughly mixed to get the final composition which has potent antiallergic activity. The invention also relates to a process for the preparation of such composition. The composition is particularly useful for the treatment of allergic conditions.

  本发明涉及一种草药抗过敏组合物，该组合物包含从诃子果实、白花蛇舌草树皮、贝母果实和欧当归中提取的协同混合物。本发明还含有瓜蒌果实、黑瓜蒌和根茎的提取物。本发明还含有胡椒（Piper longum）的果实、黑胡椒（Piper nigrum）的果实和细辛（Zingiber officinale）的根茎，经过充分混合后得到的最终组合物具有强大的抗过敏活性。本发明还涉及制备这种组合物的工艺。该组合物特别适用于治疗过敏性疾病。
• NANDY, ASHOKE K.;PODDER, GURUDAS;SAHU, NIRANJAN P.;MAHATO, SHASHI B., PHYTOCHEMISTRY, 28,(1989) N0, C. 2769-2772
  作者：NANDY, ASHOKE K.、PODDER, GURUDAS、SAHU, NIRANJAN P.、MAHATO, SHASHI B.

  DOI：——

  日期：——