2-氯-1,5-二溴-3-氟苯 | 202925-04-0

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-1,5-二溴-3-氟苯
• 中文别名: 2-氯-3，5-二溴氟苯；2-氯-3,5-二溴氟苯；1-氯2,4-二溴-6-氟苯；2-氯-3,5-二溴-1-氟苯；1,5-二溴-2-氯-3-氟苯
• 英文名称: 1-chloro-2-fluoro-4,6-dibromo-benzene
• 英文别名: 1,5-Dibromo-2-chloro-3-fluorobenzene
• CAS: 202925-04-0
• 化学式: C₆H₂Br₂ClF
• 分子量: 288.341
• InChiKey: WRJXIIFHUQBLSW-UHFFFAOYSA-N

物化性质

• 熔点：
  85-87°C
• 沸点：
  254℃
• 密度：
  2.089
• 闪点：
  107℃
• 稳定性/保质期：
  避氧化物

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S24/25
• 危险类别码：
  R36/37/38,R36/38
• 海关编码：
  2903999090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312+P330,P302+P352,P304+P340+P312,P305+P351+P338,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
2-Chloro-3,5-dibromo-1-fluorobenzene
Product Name:
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

---

Section 3. Composition/information on ingredients.
2-Chloro-3,5-dibromo-1-fluorobenzene
Ingredient name:
CAS number: 202925-04-0

---

Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C6H2Br2ClF
Molecular weight: 288.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride, hydrogen fluoride, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

2-氯-3,5-二溴氟苯是一种氟类衍生物，可作为医药中间体使用。

反应信息

• 作为反应物：
  描述：

  2-氯-1,5-二溴-3-氟苯 在 sodium hydride 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 sodium t-butanolate 、 tri tert-butylphosphoniumtetrafluoroborate 作用下， 以 N-甲基吡咯烷酮 、 甲苯 、 mineral oil 为溶剂， 反应 56.0h， 生成 C₆₀H₄₀Cl₂N₄O
  参考文献：
  名称：

  유기 전계 발광 소자 및 유기 전계 발광 소자용 축합다환 화합물

  摘要：

  这是一段描述有机发光二极管的句子，它包括第一电极，第二电极和放置在第一电极和第二电极之间的发光层。发光层包括聚合多环化合物，其化学式表示为1，可以表现出优异的发光效率。

  公开号：

  KR20210070453A
• 作为产物：
  描述：

  3-氯-2,6-二溴-4-氟苯胺 、 亚硝酸异戊酯 在 sodium hydroxide 、 乙酸乙酯 、 Brine 、 magnesium sulfate 、 正庚烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以to give desired product 2a as colorless oil (3.70 g, 80%)的产率得到2-氯-1,5-二溴-3-氟苯
  参考文献：
  名称：

  Antimicrobial Compounds and Methods of Making and Using the Same

  摘要：

  本发明通常涉及抗微生物化合物领域以及其制备和使用方法。这些化合物对于治疗、预防和减少人类和动物微生物感染的风险非常有用。

  公开号：

  US20140163049A1

文献信息

• Non-nucleoside reverse transcriptase inhibitors
  申请人：Dunn Patrick James

  公开号：US20050239881A1

  公开（公告）日：2005-10-27

  The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 7a , R 7b , R 7c , R 8 -R 10 , X 1 , X 2 m, n, o and p are as defined herein.

  本发明提供了用于治疗或预防HIV感染，治疗艾滋病或ARC的化合物，包括根据以下公式I给予化合物，其中Ar，R1-R5，R7a，R7b，R7c，R8-R10，X1，X2m，n，o和p如本文所定义。
• Methods for treating retroviral infections
  申请人：Dunn Patrick James

  公开号：US20050239880A1

  公开（公告）日：2005-10-27

  The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c and X 1 are as defined herein.

  本发明提供了用于治疗或预防HIV感染，治疗艾滋病或ARC的化合物，包括根据本文所定义的公式I给药的化合物，其中Ar、R1-R5、R11c和X1如本文所定义。
• METHODS FOR TREATING RETROVIRAL INFECTIONS
  申请人：Dunn James Patrick

  公开号：US20100041648A1

  公开（公告）日：2010-02-18

  The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c and X 1 are as defined herein with at least one carrier, excipient or diluent.

  本发明提供了用于治疗HIV感染的组合物，其包括按照式I给出的化合物与至少一种载体、赋形剂或稀释剂一起使用，其中Ar、R1-R5、R11c和X1的定义如本文所述。
• Antimicrobial compounds and methods of making and using the same
  申请人：Duffy Erin M.

  公开号：US09221827B2

  公开（公告）日：2015-12-29

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.

  本发明通常涉及抗微生物化合物领域及其制备和使用方法。这些化合物对于治疗、预防和降低人类和动物微生物感染的风险是有用的。
• 一种含硼的不对称螺环化合物及其在有机电致发光器件中的应用
  申请人：吉林大学

  公开号：CN113980040A

  公开（公告）日：2022-01-28

  一种含硼的不对称螺环化合物及其在有机电致发光器件中的应用，属于有机电致发光器件技术领域。本发明所述的含硼的不对称螺环化合物作为发光层掺杂客体材料使用，其是在高效率的含咔唑骨架三配位硼发光化合物引入氧、硫、硒等杂原子，利用重原子效应促进自旋轨道耦合来提高三重态到单线态激子的反向系间窜越速率，减弱三线态激子湮灭过程。此外，引入大体积的外围取代基来抑制分子之间的相互作用，在一定程度上可以缓解分子与分子之间的相互淬灭过程。由此制备的有机电致发光器件克服了多重共振材料在高亮度下效率衰减严重等缺点，实现了具有高效率、高色纯度和低效率滚降的有机电致发光器件，对有机电致发光技术进一步普及有重要推动作用。