6-chloroisocryptolepine | 860777-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloroisocryptolepine
• 英文别名: 6-Chloro-5-methyl-5H-indolo[3,2-c]quinoline；6-Chloro-5-methylindolo[3,2-c]quinoline；6-chloro-5-methylindolo[3,2-c]quinoline
• CAS: 860777-42-0
• 化学式: C₁₆H₁₁ClN₂
• 分子量: 266.73
• InChiKey: MUHNPRIRXLRHRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-chloroisocryptolepine 在 palladium on activated charcoal 氢气 作用下， 以70%的产率得到cryptosanguinolentine
  参考文献：
  名称：

  Fischer indole synthesis of the indoloquinoline alkaloid: cryptosanguinolentine

  摘要：

  A new synthesis of an indoloquinoline alkaloid, isolated from Cryptolepis sanguinolenta, is described using a Fischer indole cyclization. 4-Hydroxy-1-methyl-1H-quinolin-2-one reacted directly with phenylhydrazine hydrochloride to give the indoloquinoline, which was reacted with POCl3 and then the resultant halide hydrogenolysed to give cryptosanguinolentine. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.122
• 作为产物：
  描述：

  4-羟基-N-甲基-2-喹啉 在 盐酸 、 三氯氧磷 作用下， 以 溶剂黄146 为溶剂， 反应 13.0h， 生成 6-chloroisocryptolepine
  参考文献：
  名称：

  Fischer indole synthesis of the indoloquinoline alkaloid: cryptosanguinolentine

  摘要：

  A new synthesis of an indoloquinoline alkaloid, isolated from Cryptolepis sanguinolenta, is described using a Fischer indole cyclization. 4-Hydroxy-1-methyl-1H-quinolin-2-one reacted directly with phenylhydrazine hydrochloride to give the indoloquinoline, which was reacted with POCl3 and then the resultant halide hydrogenolysed to give cryptosanguinolentine. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.122

文献信息

• Fischer indole synthesis of the indoloquinoline alkaloid: cryptosanguinolentine
  作者：T. Dhanabal、R. Sangeetha、P.S. Mohan

  DOI：10.1016/j.tetlet.2005.04.122

  日期：2005.6

  A new synthesis of an indoloquinoline alkaloid, isolated from Cryptolepis sanguinolenta, is described using a Fischer indole cyclization. 4-Hydroxy-1-methyl-1H-quinolin-2-one reacted directly with phenylhydrazine hydrochloride to give the indoloquinoline, which was reacted with POCl3 and then the resultant halide hydrogenolysed to give cryptosanguinolentine. (c) 2005 Elsevier Ltd. All rights reserved.