(1E,4E)-1,5-bis[3-methoxy-4-(methoxymethoxy)phenyl]penta-1,4-dien-3-one | 148625-89-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (1E,4E)-1,5-bis[3-methoxy-4-(methoxymethoxy)phenyl]penta-1,4-dien-3-one
• CAS: 148625-89-2
• 化学式: C₂₃H₂₆O₇
• 分子量: 414.455
• InChiKey: AWUYCCFUIGEYEQ-NXZHAISVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (1E,4E)-1,5-bis[3-methoxy-4-(methoxymethoxy)phenyl]penta-1,4-dien-3-one 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以42%的产率得到(1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
  参考文献：
  名称：

  Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica

  摘要：

  Two new natural phenolics were isolated from the rhizomes of Curcuma domestica along with four known curcuminoids. The structures of the former were determined to be 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-(1E,4E)-1,4-dien-3-one and 1-(4-hydroxy-3-methoxyphenyl)-5-(-4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one, respectively, by spectral data and syntheses. Anti-oxidant activity of the phenolics was determined by the inhibition of autoxidation of linoleic acid in a water-alcohol system. Anti-inflammatory activity of the isolated compounds was determined on mouse cars by using a tumour promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) as an inducer.

  DOI：

  10.1016/0031-9422(93)85179-u
• 作为产物：
  描述：

  3-甲氧基-4-(甲氧基甲氧基)苯甲醛 、 丙酮 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以95%的产率得到(1E,4E)-1,5-bis[3-methoxy-4-(methoxymethoxy)phenyl]penta-1,4-dien-3-one
  参考文献：
  名称：

  Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica

  摘要：

  Two new natural phenolics were isolated from the rhizomes of Curcuma domestica along with four known curcuminoids. The structures of the former were determined to be 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-(1E,4E)-1,4-dien-3-one and 1-(4-hydroxy-3-methoxyphenyl)-5-(-4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one, respectively, by spectral data and syntheses. Anti-oxidant activity of the phenolics was determined by the inhibition of autoxidation of linoleic acid in a water-alcohol system. Anti-inflammatory activity of the isolated compounds was determined on mouse cars by using a tumour promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) as an inducer.

  DOI：

  10.1016/0031-9422(93)85179-u

文献信息

• Cancer treatment using curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20060276536A1

  公开（公告）日：2006-12-07

  Cancer or a precancerous condition is treated by administering a curcumin derivative to a subject.

  癌症或癌前病变可以通过向受试者施用姜黄素衍生物来治疗。
• Therapeutic curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20070060644A1

  公开（公告）日：2007-03-15

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素和治疗疾病的方法。
• THERAPEUTIC CURCUMIN DERIVATIVES
  申请人：STC.UNM

  公开号：US20150011494A1

  公开（公告）日：2015-01-08

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素及其方法，用于治疗疾病。
• US8841326B2
  申请人：——

  公开号：US8841326B2

  公开（公告）日：2014-09-23
• US9187397B2
  申请人：——

  公开号：US9187397B2

  公开（公告）日：2015-11-17