2-氯-3-羟基丁醛 | 69239-48-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氯-3-羟基丁醛
• 英文名称: 2-chloro-3-hydroxy-butyraldehyde
• 英文别名: 2-Chlor-3-hydroxy-butyraldehyd；α-Chlor-β-hydroxybutyraldehyd；2-Chlor-3-hydroxy-3-methyl-propanal；2-Chloro-3-hydroxybutanal
• CAS: 69239-48-1
• 化学式: C₄H₇ClO₂
• 分子量: 122.551
• InChiKey: PRCWOCJJGJKRSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯-3-羟基丁醛 在 metavanadic acid 、 氧气 、 溶剂黄146 作用下， 生成 2-氯-3-羟基-丁酸
  参考文献：
  名称：

  Manufacture of hydroxy acids

  摘要：

  公开号：

  US02411700A1
• 作为产物：
  描述：

  丁烯-2-醛 在 水 、 氯 作用下， 生成 2-氯-3-羟基丁醛
  参考文献：
  名称：

  Reflex effects of independent stimulation of coronary and left ventricular mechanoreceptors in anaesthetised dogs

  摘要：

  1. Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated.2. Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic basoreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses.3. Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35 +/- 1.9 and 40 +/- 2.5%, respectively. Intracoronary injections of veratridine (30-60 mug) decreased vascular resistance by 31 +/- 2.5%. However, pressure decreased resistance by only 9 +/- 2.2%. large increases in ventricular4. Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response.5. These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia.

  DOI：

  10.1111/j.1469-7793.2000.00349.x

文献信息

• DE559329
  申请人：——

  公开号：——

  公开（公告）日：——
• Production of methyl glycerol
  申请人：DISTILLERS CO YEAST LTD

  公开号：US02351302A1

  公开（公告）日：1944-06-13
• Method of making a 3-halo-2-methylquinoline
  申请人：EASTMAN KODAK CO

  公开号：US02507146A1

  公开（公告）日：1950-05-09
• DE699771
  申请人：——

  公开号：——

  公开（公告）日：——
• Benzanthrones and a process of preparing them
  申请人：GEN ANILINE & FILM CORP

  公开号：US02295649A1

  公开（公告）日：1942-09-15