[(1R,4S)-1-methyl-4-phenylmethoxycyclopent-2-en-1-yl]methoxymethylbenzene | 359643-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1R,4S)-1-methyl-4-phenylmethoxycyclopent-2-en-1-yl]methoxymethylbenzene
• CAS: 359643-91-7
• 化学式: C₂₁H₂₄O₂
• 分子量: 308.42
• InChiKey: QNXJKZVAFJTFIN-RTWAWAEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(1R,4S)-1-methyl-4-phenylmethoxycyclopent-2-en-1-yl]methoxymethylbenzene 在 palladium on activated charcoal 咪唑 、 chromium dichloride 、 甲醇 、 ruthenium trichloride 、 sodium periodate 、 四氧化锇 、 氯化亚砜 、 N-甲基吲哚酮 、 草酰氯 、 氢气 、 sodium hydride 、 potassium carbonate 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 四氯化碳 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 丙酮 、 乙腈 为溶剂， 生成 (2R,3S,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-((E)-2-iodo-vinyl)-2-methoxy-4-methyl-cyclopentanone
  参考文献：
  名称：

  Studies directed toward the synthesis of viridenomycin. Route 2: a second generation approach

  摘要：

  A second generation approach toward the synthesis of viridenomycin is described. Three key fragments of the molecule have been synthesized in stereochemically pure form. Initial studies toward the coupling of these fragments with the aim of assembling the macrocycle are detailed. Final efforts to reach the title compound are documented. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00701-8
• 作为产物：
  描述：

  溴甲苯 、 (1S,4R)-4-Benzyloxymethyl-4-methyl-cyclopent-2-enol 在 potassium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 [(1R,4S)-1-methyl-4-phenylmethoxycyclopent-2-en-1-yl]methoxymethylbenzene
  参考文献：
  名称：

  Studies directed toward the synthesis of viridenomycin. Route 2: a second generation approach

  摘要：

  A second generation approach toward the synthesis of viridenomycin is described. Three key fragments of the molecule have been synthesized in stereochemically pure form. Initial studies toward the coupling of these fragments with the aim of assembling the macrocycle are detailed. Final efforts to reach the title compound are documented. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00701-8

文献信息

• Studies directed toward the synthesis of viridenomycin. Route 2: a second generation approach
  作者：Alex G Waterson、Albert W Kruger、A.I Meyers

  DOI：10.1016/s0040-4039(01)00701-8

  日期：2001.6

  A second generation approach toward the synthesis of viridenomycin is described. Three key fragments of the molecule have been synthesized in stereochemically pure form. Initial studies toward the coupling of these fragments with the aim of assembling the macrocycle are detailed. Final efforts to reach the title compound are documented. (C) 2001 Elsevier Science Ltd. All rights reserved.