2-氯-4，6-二氟苯酚 | 2267-99-4

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 酚及其卤化、磺化、硝化或亚硝化衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-氯-4，6-二氟苯酚
• 中文别名: 2-氯-4,6-二氟苯酚
• 英文名称: 2-chloro-4,6-difluoro-phenol
• 英文别名: 2-Chlor-4,6-difluor-phenol；2-Chloro-4,6-difluorophenol
• CAS: 2267-99-4
• 化学式: C₆H₃ClF₂O
• 分子量: 164.539
• InChiKey: BIMMYORCXVUELS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2908199090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2-氯-4，6-二氟苯酚 以 乙醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-chloro-N-(4,6-difluorobenzo[d]thiazol-2-yl)acetamide
  参考文献：
  名称：

  Design of a delivery vehicle chitosan-based self-assembling: controlled release, high hydrophobicity, and safe treatment of plant fungal diseases

  摘要：

  Traditional pesticides are poorly water-soluble and suffer from low bioavailability. N-succinyl chitosan (NSCS) is a water-soluble chitosan derivative, has been recently used to encapsulate hydrophobic drugs to improve their bioavailability. However, it remains challenging to synthesize pesticides of a wide variety of water-soluble drugs and to scale up the production in a continuous manner.

  A synthetic method for preparing water-soluble nanopesticides with a polymer carrier was applied. The bioactive molecule BTL-11 was loaded into hollow NSCS to promote drug delivery, improve solubility and anti-fungal activity. The synthesized nanopesticides had well controlled sizes of 606 nm and the encapsulation rate was 80%. The release kinetics, drug toxicity and drug activity were further evaluated. The inhibitory activity of nanopesticides against Rhizoctonia solani (R. solani) was tested in vivo and in vitro. In vivo against R. solani trials revealed that BTL-11 has excellent control efficiency for cultivated rice leaf and sheath was 79.6 and 76.5%, respectively. By contrast, for BTL-11@NSCS NPs, the anti-fungal ability was strongly released and afforded significant control efficiencies of 85.9 and 81.1%. Those effects were significantly better than that of the agricultural fungicide azoxystrobin (51.5 and 66.5%). The proposed mechanism was validated by successfully predicting the synthesis outcomes.

  This study demonstrates that NSCS is a promising biocompatible carrier, which can enhance the efficacy of pesticides, synergistically improve plant disease resistance, protect crop growth, and can be used for the delivery of more insoluble pesticides.

  DOI：

  10.1186/s12951-024-02386-8
• 作为产物：
  描述：

  2,4-二氟苯胺 在 硫酸 、 氯 、 sodium nitrite 作用下， 生成 2-氯-4，6-二氟苯酚
  参考文献：
  名称：

  Aromatic Fluorine Compounds. VIII. Plant Growth Regulators and Intermediates^1,2

  摘要：

  DOI：

  10.1021/ja01510a021

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE LA DIHYDROOROTATE DÉSHYDROGÉNASE
  申请人：JANSSEN BIOTECH INC

  公开号：WO2021156787A1

  公开（公告）日：2021-08-12

  Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Embodiments of such compounds are represented by Formula (I) and Formula (II) as follows: and wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, X4, Y and Z, are defined herein.

  本文披露了一种通过调节DHODH来治疗受影响的疾病、紊乱或医疗状况的化合物、组合物和方法。这些化合物的实施例由以下的化学式(I)和化学式(II)表示：其中R1、R2、R3、R4、R5、R6、R7、R8、X1、X2、X3、X4、Y和Z在此定义。
• Pyrimidine compounds and their use
  申请人：——

  公开号：US20040077669A1

  公开（公告）日：2004-04-22

  Pyrimidine compounds of formula (1): 1 wherein R 1 is C 3 -C 7 alkynyl optionally substituted with halogen; R 2 and R 3 are independently hydrogen or the like; and R 4 is C 3 -C 7 alkynyloxy optionally substituted with halogen, optionally substituted phenyl, or the like have an excellent pesticidal effect.

  公式（1）的嘧啶化合物：1其中R1是C3-C7炔基，可选地取代卤素; R2和R3分别是氢或类似物; R4是C3-C7炔氧基，可选地取代卤素，可选地取代苯基或类似物，具有优异的杀虫效果。
• Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors
  申请人：AMEGEN INC.

  公开号：US20160214971A1

  公开（公告）日：2016-07-28

  The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.

  本发明提供了公式（Ia）的化合物及其药学上可接受的盐。这些化合物可用作电压门控钠通道的抑制剂，特别是Nav 1.7，如规范中所述。这些化合物可用于治疗可通过抑制钠通道治疗的疾病，例如疼痛障碍。还提供了含有本发明化合物的制药组合物，以及制造这些化合物的中间体和工艺。
• [EN] HALOGEN-SUBSTITUTED PYRIDAZINONE COMPOUND AND APPLICATION THEREOF<br/>[FR] COMPOSÉ DE PYRIDAZINONE À SUBSTITUTION HALOGÈNE ET SON APPLICATION<br/>[ZH] 卤素取代的哒嗪酮类化合物及其应用
  申请人：[en]MEDSHINE DISCOVERY INC.;[zh]南京明德新药研发有限公司

  公开号：WO2023036312A1

  公开（公告）日：2023-03-16

  一种卤素取代的哒嗪酮类化合物及其应用，具体公开了式(I)所示化合物或其药学上可接受的盐。
• PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP1366026B1

  公开（公告）日：2004-12-01