Transition-metal-free solid phase synthesis of 1,2-disubstituted 4-quinolones via the regiospecific synthesis of enaminones
作者:Ajjampura C. Vinayaka、Toreshettahally R. Swaroop、Prasanna Kumara Chikkade、Kanchugarakoppal S. Rangappa、Maralinganadoddi P. Sadashiva
DOI:10.1039/c5ra21421a
日期:——
Herein, the transition-metal-free economical solidphasesynthesis of 1,2-disubstituted 4-quinolones has been developed via the novel regiospecific synthesis of enaminones. Notably, a wide range of enaminones were synthesized via a silica-supported solid-phase reaction in good to excellent yields. The transformation of enaminones to 1,2-disubstituted 4-quinolones and N-methyl-2-aryl-4-quinolone alkaloid