N-acetyl-3-phenylbicyclo[2.2.1]heptan-2-amine | 85267-40-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-acetyl-3-phenylbicyclo[2.2.1]heptan-2-amine
• 英文别名: N-(3-Phenylbicyclo[2.2.1]heptan-2-yl)acetamide；N-(3-phenyl-2-bicyclo[2.2.1]heptanyl)acetamide
• CAS: 85267-40-9
• 化学式: C₁₅H₁₉NO
• 分子量: 229.322
• InChiKey: MNUMESDXWPVHHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (-)-2-Phenylnorbornen-(2) 在 lithium perchlorate 作用下， 以 乙腈 为溶剂， 以4%的产率得到N-acetyl-3-phenylbicyclo[2.2.1]heptan-2-amine
  参考文献：
  名称：

  Curve crossing in the cyclic voltammetric oxidation of 2-phenylnorbornene. Evidence for an ECE reaction pathway

  摘要：

  DOI：

  10.1021/ja00349a014

文献信息

• [EN] PRODRUGS OF FENCAMFAMINE<br/>[FR] PROMÉDICAMENTS DE FENCAMFAMINE
  申请人：PRAXIS BIOSCIENCES LLC

  公开号：WO2017048720A1

  公开（公告）日：2017-03-23

  Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

  本文披露了包含芬卡麦非或芬卡麦非相关的前药衍生物的药物组合物，用于靶向治疗应用，并且披露了合成这些组合物的方法。
• Prodrugs of fencamfamine
  申请人：Praxis Bioresearch, LLC

  公开号：US10662146B2

  公开（公告）日：2020-05-26

  Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.

  本文公开了含有芬卡胺或芬卡胺相关原药衍生物的药物组合物。这些药物组合物用于靶向治疗应用，包括但不限于治疗癌症相关性疲劳、阿尔茨海默病的冷漠症、重度抑郁症和注意缺陷多动障碍。还公开了芬卡胺或芬卡胺相关原药衍生物合成药物组合物的方法。
• PRODRUGS OF FENCAMFAMINE
  申请人：Praxis Bioresearch, LLC

  公开号：US20190023650A1

  公开（公告）日：2019-01-24

  Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
• Curve crossing in the cyclic voltammetric oxidation of 2-phenylnorbornene. Evidence for an ECE reaction pathway
  作者：Marye Anne Fox、Ryoichi Akaba

  DOI：10.1021/ja00349a014

  日期：1983.6