5-phenoxy-(3',5'-dimethoxyphenyl)pent-1-one | 215649-00-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-phenoxy-(3',5'-dimethoxyphenyl)pent-1-one
• 英文别名: 3,5-Dimethoxy-delta-phenoxyvalerophenone；1-(3,5-dimethoxyphenyl)-5-phenoxypentan-1-one
• CAS: 215649-00-6
• 化学式: C₁₉H₂₂O₄
• 分子量: 314.381
• InChiKey: MBTMVURQGKOONE-UHFFFAOYSA-N

物化性质

• 沸点：
  468.6±35.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-phenoxy-(3',5'-dimethoxyphenyl)pent-1-one 在 三溴化硼 、 四氯化钛 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 4.17h， 生成 5'-bromo-1',1'-dimethyl-Δ⁸-tetrahydrocannabinol
  参考文献：
  名称：

  Potent Cyano and Carboxamido Side-Chain Analogues of 1‘,1‘-Dimethyl-Δ⁸-Tetrahydrocannabinol

  摘要：

  The synthesis and pharmacological profile of several cyano (1a-e) and carboxamido (2a-h) side-chain-substituted analogues of 1',1'-dimethyl-Delta(8)-THC are described. Commercially available cyano compound 3 was transformed to the resorcinol 6 in a three-step sequence. Condensation of 6 with p-menth-2-ene-1,8-diol formed the THC 7a which, with sodium cyanide/ DMSO, gave Ib. Protection of the phenol in 7a as the MOM derivative provided the common intermediate 8 for the synthesis of 1a,c,e. Compound 1d was also synthesized from 7a via the aldehyde 9a. Base hydrolysis of 1b gave the acid 10 which, via its acid chloride and subsequent treatment with the appropriate amine, formed the target compounds 2a-h. The pharmacological profile indicated that the cyano analogues 1a-e had very high CB1 binding affinity (0.36-13 nM) and high in vivo potency as agonists. Two analogues (1a,b) had extremely high potency in the mouse tetrad tests. The dimethylcarboxamido analogue 2a showed a similar profile to 1a,b. The high potency was also retained in analogue 2c. In contrast the sulfonamide analogue 2d was unique as it had greater affinity than Delta(9)-THC, yet it was practically devoid of agonist effects. This study suggests that the incorporation of a cyano or an amide substituent in the side chain of Delta(8)-THC-DMH can enhance potency and can also lead to compounds with a unique profile which have high binding affinity and are practically devoid of agonist effects.

  DOI：

  10.1021/jm9803875
• 作为产物：
  描述：

  (4-phenoxybutyl)magnesium bromide 、 3,5-二甲氧基苯腈 在 盐酸 作用下， 生成 5-phenoxy-(3',5'-dimethoxyphenyl)pent-1-one
  参考文献：
  名称：

  Potent Cyano and Carboxamido Side-Chain Analogues of 1‘,1‘-Dimethyl-Δ⁸-Tetrahydrocannabinol

  摘要：

  The synthesis and pharmacological profile of several cyano (1a-e) and carboxamido (2a-h) side-chain-substituted analogues of 1',1'-dimethyl-Delta(8)-THC are described. Commercially available cyano compound 3 was transformed to the resorcinol 6 in a three-step sequence. Condensation of 6 with p-menth-2-ene-1,8-diol formed the THC 7a which, with sodium cyanide/ DMSO, gave Ib. Protection of the phenol in 7a as the MOM derivative provided the common intermediate 8 for the synthesis of 1a,c,e. Compound 1d was also synthesized from 7a via the aldehyde 9a. Base hydrolysis of 1b gave the acid 10 which, via its acid chloride and subsequent treatment with the appropriate amine, formed the target compounds 2a-h. The pharmacological profile indicated that the cyano analogues 1a-e had very high CB1 binding affinity (0.36-13 nM) and high in vivo potency as agonists. Two analogues (1a,b) had extremely high potency in the mouse tetrad tests. The dimethylcarboxamido analogue 2a showed a similar profile to 1a,b. The high potency was also retained in analogue 2c. In contrast the sulfonamide analogue 2d was unique as it had greater affinity than Delta(9)-THC, yet it was practically devoid of agonist effects. This study suggests that the incorporation of a cyano or an amide substituent in the side chain of Delta(8)-THC-DMH can enhance potency and can also lead to compounds with a unique profile which have high binding affinity and are practically devoid of agonist effects.

  DOI：

  10.1021/jm9803875

文献信息

• Water Soluble Cannabinoids
  申请人：Martin Billy R.

  公开号：US20080064679A1

  公开（公告）日：2008-03-13

  Water-soluble cannabinoid compounds that are agonists of CB 1 and CB 2 cannabinoid receptors are provided. The compounds are made water-soluble by derivatization of the alkyl side chain and/or the phenolic hydroxyl group of tetrahydrocannabinol. The water-soluble cannabinoids are useful for the treatment of appetite loss, pain, multiple sclerosis, nausea and vomiting, and epilepsy.
• Potent Cyano and Carboxamido Side-Chain Analogues of 1‘,1‘-Dimethyl-Δ⁸-Tetrahydrocannabinol
  作者：Michael Singer、William J. Ryan、Bijali Saha、Billy R. Martin、Raj K. Razdan

  DOI：10.1021/jm9803875

  日期：1998.10.1

  The synthesis and pharmacological profile of several cyano (1a-e) and carboxamido (2a-h) side-chain-substituted analogues of 1',1'-dimethyl-Delta(8)-THC are described. Commercially available cyano compound 3 was transformed to the resorcinol 6 in a three-step sequence. Condensation of 6 with p-menth-2-ene-1,8-diol formed the THC 7a which, with sodium cyanide/ DMSO, gave Ib. Protection of the phenol in 7a as the MOM derivative provided the common intermediate 8 for the synthesis of 1a,c,e. Compound 1d was also synthesized from 7a via the aldehyde 9a. Base hydrolysis of 1b gave the acid 10 which, via its acid chloride and subsequent treatment with the appropriate amine, formed the target compounds 2a-h. The pharmacological profile indicated that the cyano analogues 1a-e had very high CB1 binding affinity (0.36-13 nM) and high in vivo potency as agonists. Two analogues (1a,b) had extremely high potency in the mouse tetrad tests. The dimethylcarboxamido analogue 2a showed a similar profile to 1a,b. The high potency was also retained in analogue 2c. In contrast the sulfonamide analogue 2d was unique as it had greater affinity than Delta(9)-THC, yet it was practically devoid of agonist effects. This study suggests that the incorporation of a cyano or an amide substituent in the side chain of Delta(8)-THC-DMH can enhance potency and can also lead to compounds with a unique profile which have high binding affinity and are practically devoid of agonist effects.