3a,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-3,4-dione | 79402-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3a,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-3,4-dione
• CAS: 79402-15-6
• 化学式: C₇H₈O₃
• 分子量: 140.139
• InChiKey: CCBREHOOSSYADI-UHFFFAOYSA-N

物化性质

• 沸点：
  343.4±25.0 °C(Predicted)
• 密度：
  1.309±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3a,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-3,4-dione 在 sodium hydride 、 potassium carbonate 、 臭氧 、 二乙胺 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 生成 3-methyl-2-(2-pentynyl)-2-cyclopentenone
  参考文献：
  名称：

  β-酮内酯合成子。茉莉花的有效合成方法。

  摘要：

  相当于3-烷基环戊酮的特定烯醇化物的环戊烷β-酮内酯已被转化为几种茉莉酮类物质。

  DOI：

  10.1016/s0040-4039(01)92929-6
• 作为产物：
  描述：

  methyl ((3-oxocyclopentyl)methyl) carbonate 在 potassium tert-butylate 作用下， 以 乙醚 、 叔丁醇 为溶剂， 反应 0.33h， 以93%的产率得到3a,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-3,4-dione
  参考文献：
  名称：

  β-酮内酯合成子。茉莉花的有效合成方法。

  摘要：

  相当于3-烷基环戊酮的特定烯醇化物的环戊烷β-酮内酯已被转化为几种茉莉酮类物质。

  DOI：

  10.1016/s0040-4039(01)92929-6

文献信息

• Total Synthesis of (±)-Merrilactone A
  作者：Wei He、Jie Huang、Xiufeng Sun、Alison J. Frontier

  DOI：10.1021/ja0761986

  日期：2008.1.1

  The total synthesis of racemic merrilactone A (a neurotrophic agent) is described, featuring simultaneous and stereospecific creation of the C4 and C5 stereocenters via a notable silyloxyfuran Nazarov cyclization. Full details of the successful synthetic strategy are given, as well as several examples of the interesting reactivity of intermediates that were prepared and studied during the execution

  描述了外消旋 merrilactone A（一种神经营养剂）的全合成，其特点是通过显着的甲硅烷氧基呋喃 Nazarov 环化同时和立体定向地创建 C4 和 C5 立体中心。给出了成功合成策略的完整细节，以及在执行全合成过程中制备和研究的中间体的有趣反应性的几个例子。对路易斯酸催化的甲硅烷氧基呋喃 Nazarov 环化进行了详细研究，包括对底物范围和局限性的系统研究。此外，进行的实验表明路易斯酸性硅物质参与了纳扎罗夫环化。
• PERMANENT HYDROPHILIC POROUS COATINGS AND METHODS OF MAKING THEM
  申请人：Moore David Roger

  公开号：US20090188857A1

  公开（公告）日：2009-07-30

  A membrane includes a porous base membrane and a hydrophilic coating. The coating comprises a hydrophilic additive and a hydrophilic polymer derivatized with an electron beam reactive group adapted to form a radical under high energy irradiation. In some embodiments, the membrane comprises a fluoropolymer. Also disclosed are processes for forming the membrane.
• PROCESSES FOR FORMING PERMANENT HYDROPHILIC POROUS COATINGS ONTO A SUBSTRATE, AND POROUS MEMBRANES THEREOF
  申请人：Moore David Roger

  公开号：US20090191357A1

  公开（公告）日：2009-07-30

  A membrane includes a base membrane; and an electron beam functionalized coating, the coating comprising a polyvinyl alcohol, a polyvinyl alcohol-polyvinyl amine copolymer, a polyvinyl amine, and derivatives thereof functionalized with an electron beam reactive group adapted to form a radical under high energy irradiation. Also disclosed are processes for forming the membrane.
• MEMBRANES COMPRISING HYDROPHILIC COATINGS
  申请人：Moore David Roger

  公开号：US20090191398A1

  公开（公告）日：2009-07-30

  The present invention provides a membrane useful for water purification comprising a porous base membrane and a hydrophilic coating disposed on the porous base membrane. The hydrophilic coating comprises structural units derived from a hydrophilic polymer and structural units derived from a first electron beam reactive group, and structural units derived from a second electron beam reactive group. The hydrophilic polymer has a number average molecular weight of greater than 2500 Daltons and comprises at least two electron beam reactive groups having different structures. The hydrophilic coating is covalently bound to the porous base membrane through structural units derived from the electron beam reactive groups. Also disclosed are processes for forming and employing the membrane.
• PERMANENT HYDROPHILIC POROUS COATINGS ONTO A SUBSTRATE AND POROUS MEMBRANES THEREOF
  申请人：Moore David Roger

  公开号：US20090191399A1

  公开（公告）日：2009-07-30

  A membrane includes a base membrane; and an electron beam functionalized coating, the coating comprising a polyvinyl alcohol, a polyvinyl alcohol-polyvinyl amine copolymer, a polyvinyl amine, and derivatives thereof functionalized with an electron beam reactive group adapted to form a radical under high energy irradiation. Also disclosed are processes for forming the membrane.