7-isopropylidenebicyclo<2.2.1>hept-5-ene-2,3-cis-endo-dicarboxylic anhydride | 455279-88-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-isopropylidenebicyclo<2.2.1>hept-5-ene-2,3-cis-endo-dicarboxylic anhydride
• 英文别名: 7-isopropylidenebicyclo<2.2.1>hept-5-ene-2,3-cis-exo-dicarboxylic anhydride；7-isopropylidene-norborn-5-ene-2,3-dicarboxylic acid-anhydride；7-Isopropyliden-norborn-5-en-2,3-dicarbonsaeure-anhydrid；7-isopropylidenebicyclo[2.2.1]hept-5-ene-2,3-cis-endo-dicarboxylic anhydride；7-isopropylidenebicyclo[2.2.1]hept-5-ene-2,3-cis-exo-dicarboxylic anhydride；10-Propan-2-ylidene-4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• CAS: 455279-88-6
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: LEVGEMOUBVHJCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-isopropylidenebicyclo<2.2.1>hept-5-ene-2,3-cis-endo-dicarboxylic anhydride 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成 Dimethyl 7-Isopropylidenebicyclo<2.2.1>heptane-exo-2,exo-3-dicarboxylate
  参考文献：
  名称：

  Dimerization and cycloaddition reactions of a trimethylenemethane derivative, 2-isopropylidenecyclopenta-1,3-diyl. Mechanistic separation of triplet and singlet reactions

  摘要：

  DOI：

  10.1021/ja00521a044
• 作为产物：
  描述：

  马来酸酐 、 6,6-二甲基-5-亚甲基-1,3-环戊二烯 在 苯 作用下， 生成 7-isopropylidenebicyclo<2.2.1>hept-5-ene-2,3-cis-endo-dicarboxylic anhydride
  参考文献：
  名称：

  Diels; Alder, Chemische Berichte, 1929, vol. 62, p. 2088

  摘要：

  DOI：

文献信息

• DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY
  申请人：Beard Richard L.

  公开号：US20110319454A1

  公开（公告）日：2011-12-29

  The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.

  本发明提供了具有FPRL-1激动剂或拮抗剂活性的明确定义的化合物。因此，本发明的化合物可用于治疗各种眼部疾病。
• Photosensitive polyimide compositions
  申请人：Fujifilm Electronic Materials U.S.A., Inc.

  公开号：US10036952B2

  公开（公告）日：2018-07-31

  This disclosure relates to a photosensitive composition that includes at least one fully imidized polyimide polymer having a weight average molecular weight in the range of about 20,000 Daltons to about 70,000 Daltons; at least one solubility switching compound; at least one photoinitiator; and at least one solvent. The composition is capable of forming a film or a dry film having a dissolution rate of greater than about 0.15 micron/second using cyclopentanone as a developer.

  本公开涉及一种光敏组合物，它包括至少一种重量平均分子量在约 20,000 道尔顿至约 70,000 道尔顿范围内的全亚胺化聚酰亚胺聚合物；至少一种溶解度切换化合物；至少一种光引发剂；以及至少一种溶剂。使用环戊酮作为显影剂，该组合物能够形成溶解速率大于约 0.15 微米/秒的薄膜或干膜。
• Polymer and thermosetting composition containing same
  申请人：Fujifilm Electronic Materials U.S.A., Inc.

  公开号：US10604628B2

  公开（公告）日：2020-03-31

  This disclosure relates to a polymer that includes a first repeat unit and at least one end-cap group at one end of the polymer. The first repeat unit includes at least one imide moiety and at least one indane-containing moiety. The end-cap group is capable of undergoing a cycloreversion reaction. This disclosure also relates to a thermosetting composition containing the above polymer.

  本公开涉及一种聚合物，它包括一个第一重复单元和位于聚合物一端的至少一个端帽基团。第一重复单元包括至少一个亚胺分子和至少一个含茚分子。端帽基团能够发生环化反应。本公开还涉及一种含有上述聚合物的热固性组合物。
• A ranking of diylophilic reactivities of olefins toward the singlet and triplet forms of the trimethylenemethane biradical, 2-isopropylidenecyclopenta-1,3-diyl
  作者：Charles D. Duncan、Leonard R. Corwin、James H. Davis、Jerome A. Berson

  DOI：10.1021/ja00527a037

  日期：1980.3
• Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies
  作者：Magid Abou-Gharbia、Usha R. Patel、Michael B. Webb、John A. Moyer、Terrance H. Andree、Eric A. Muth

  DOI：10.1021/jm00402a023

  日期：1988.7

  A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests. Parameters measured included in vitro inhibition of D2 and 5-HT1A receptor binding, inhibition of apomorphine (APO) induced stereotyped and climbing behavior, and activity in blocking conditioned avoidance responding (CAR). Several compounds demonstrated moderate to high affinity for the 5-HT1A receptor binding site; compounds 27 and 36 containing the serotonin mimetic (o-methoxyphenyl)piperazinyl moiety and compounds 42 and 50 containing the 2-pyrimidinylpiperazinyl moiety displayed the highest affinity, being equal to that of the 5-HT1A agonist 8-OH-DPAT (Ki = 1-1.3 nM). In addition to affinity at 5-HT1A binding sites, many compounds were active in blocking CAR. Compound 34, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]hexahydro-4,7-etheno-1H- cyclobut[f]isoindole-1,3(2H)-dione, demonstrated 3 times the activity of buspirone, blocking CAR in rats with an AB50 of 13 mg/kg. It also displayed high affinity for the 5-HT1A receptor (Ki = 16 nM), which is at least 20 times higher than its affinity for D2 (Ki = 345 nM) and 5-HT2 (Ki = 458 nM) receptors. Compound 34 was selected for further preclinical and pharmacokinetic evaluations for possible development as an anxiolytic agent. Structure-activity relationships within this series are discussed.