3β-Hydroxy-23,24-bisnorchol-5-en-22-oic Acid | 19408-50-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-Hydroxy-23,24-bisnorchol-5-en-22-oic Acid
• 英文别名: 3β-hydroxy-24-norchol-5-en-23-oic acid；3β-Hydroxynorchol-5-en-23-carbonsaeure；3β-Hydroxy-24-nor-chol-5-en-23-saeure；3β-Hydroxy-24-nor-cholen-(5)-saeure-(23)；(3R)-3-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]butanoic acid
• CAS: 19408-50-5
• 化学式: C₂₃H₃₆O₃
• 分子量: 360.537
• InChiKey: XAFQBISUIKGUJZ-IRJIZISJSA-N

物化性质

• 熔点：
  244.5-245.0 °C
• 沸点：
  511.7±23.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3β-Hydroxy-23,24-bisnorchol-5-en-22-oic Acid 在 lithium aluminium tetrahydride 、 正丁基锂 、 正己烷 、 三氟化硼乙醚 、 对甲苯磺酸 、 sodium iodide 、 mercury(II) oxide 作用下， 以 吡啶 、 丙酮 为溶剂， 反应 57.0h， 生成 (20R)-20-(2-hydroxyethyl)-5-pregnen-3β-ol tetrahydropyranyl ether
  参考文献：
  名称：

  The C-25 chirality of 26-hydroxycholesterol

  摘要：

  DOI：

  10.1021/jo00332a028
• 作为产物：
  描述：

  methyl 3β-acetoxy-24-norchol-5-en-23-oate 在 氢氧化钾 作用下， 生成 3β-Hydroxy-23,24-bisnorchol-5-en-22-oic Acid
  参考文献：
  名称：

  ÜberSteroide和性激素。（86. Mitteilung）。亲水性产品Δ5,6 ; 20,22-3β -Oxy-nor-choladiensäure

  摘要：

  DOI：

  10.1002/hlca.19430260427

文献信息

• NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
  申请人：SAGE THERAPEUTICS, INC.

  公开号：US20160022701A1

  公开（公告）日：2016-01-28

  Provided are methods of evaluating or treating a patient, e.g., a patient having a disorder described herein, comprising: a) optionally, acquiring a patient sample; b) acquiring an evaluation of and/or evaluating the sample for an alteration in the level S24(S)-hydroxycholesterol compared to a reference standard.

  提供了评估或治疗患者的方法，例如，患有本文所述疾病的患者，包括：a) 可选地，获取患者样本；b) 获取对样本的评估和/或评估其S24(S)-羟基胆固醇水平与参考标准相比是否发生改变。
• 3β-Acetoxy-17α-hydroxynor-5-cholenic Acid Lactone, a By-product of the Oxidation of Sitosterol
  作者：August I. Ryer、William H. Gebert

  DOI：10.1021/ja01121a011

  日期：1952.1
• Valuable degradation products of sterols and a method of producing the same
  申请人：SCHERING CORP

  公开号：US02180095A1

  公开（公告）日：1939-11-14
• Fujii; Matsukawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1936, vol. 56, p. 433,439; dtsch. Ref. S. 93
  作者：Fujii、Matsukawa

  DOI：——

  日期：——
• Bending strength and toughness of heat-treated wood
  作者：Yoshitaka Kubojima、Takeshi Okano、Masamitsu Ohta

  DOI：10.1007/bf00779547

  日期：2000.2

  The load-deflection curve for static bending and the force-time curve for impact bending of heat-treated wood were examined in detail. The effect of oxygen in air was also investigated. Sitka spruce (Picea sitchensis Carr.) was heated for 0.5-16.0h at a temperature of 160 degrees C in nitrogen gas or air. The dynamic Young's modulus was measured by the free-free flexural vibration test, the static Young's modulus and work needed for rupture by the static bending test, and the absorbed energy in impact bending by the impact bending test. The results obtained were as follows: (1) The static Young's modulus increased at the initial stage of the heat treatment and decreased later. It decreased more in air than in nitrogen. (2) The bending strength increased at the initial stage of the heat treatment and decreased later. It decreased more in air than in nitrogen. (3) The work needed for rupture decreased steadily as the heating lime increased. It decreased more in nitrogen than in air. It is thought that heat-treated wood was more brittle than untreated wood in the static bending test because , was reduced by the heat treatment. This means that the main factors contributing to the reduction of the work needed for rupture were viscosity and plasticity, not elasticity. (4) The absorbed energy in impact bending increased at the initial stage of the heat treatment and decreased later. It decreased more in air than in nitrogen. It was concluded that heat-treated wood became more brittle in the impact bending test because I-12 and I-23, were reduced by the heat treatment.